Journal
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
Volume 12, Issue 1, Pages 6-16Publisher
SPRINGER
DOI: 10.1007/s11481-016-9687-4
Keywords
Dual targeting; Brain tumor; Blood brain barrier; Drug delivery systems
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Funding
- National Natural Science Foundation of China [81402866, 31571016]
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Brain tumor remains one of the most serious threats to human beings. Different from peripheral tumors, drug delivery to brain tumor is largely restricted by the blood brain barrier (BBB). To fully conquer this barrier and specifically deliver drugs to brain tumor, dual targeting delivery systems were explored, which are functionalized with two active targeting ligands: one to the BBB and the other to the brain tumor. The development of dual targeting delivery system is still in its early stage, and attentions need to be paid to issues and concerns that remain unresolved in future studies.
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