Journal
ADVANCES IN ANATOMIC PATHOLOGY
Volume 30, Issue 5, Pages 320-335Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAP.0000000000000393
Keywords
melanoma; glioma; glioblastoma; melanoma-astrocytoma syndrome; genetics
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This article investigates the relationship between malignant melanoma and primary glioblastoma through literature analysis. It provides an overview of both cancers, case reports, epidemiologic studies, and common genetic abnormalities. From a scientific perspective, the evidence supports an association between melanoma and glioma.
Recently, we came across a patient with malignant melanoma and primary glioblastoma. Given this, we parsed the literature to ascertain the relationship, if any, between these 2 malignancies. We begin with a brief overview of melanoma and glioma in isolation followed by a chronologic overview of case reports and epidemiologic studies documenting both neoplasms. This is followed by studies detailing genetic abnormalities common to both malignancies with a view to identifying unifying genetic targets for therapeutic strategies as well as to explore the possibility of a putative association and an inherited cancer susceptibility trait. From a scientific perspective, we believe we have provided evidence favoring an association between melanoma and glioma. Future studies that include documentation of additional cases, as well as a detailed molecular analyses, will lend credence to our hypothesis that the co-occurrence of these 2 conditions is likely not serendipitous.
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