Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 364, Issue 24, Pages 4421-4426Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202200965
Keywords
Highly regioselective; 2-Acylindolines; Cobalt-catalysis; C-H activation; [3+2] annulation
Categories
Funding
- National Key R&D Program of China [21662043]
- NSFC [2019FY003010]
- NSF of Yunnan [202207AA11000]
- IRTSTYN
- Postgraduate Research and Innovation Foundation of Yunnan University [2021Y041]
- Central Government Guides Local Science and Technology Development Fund [202207AA110007, 202207AB110002]
- Program for Xingdian Talents (Yun-Ling Scholars)
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This paper describes an approach for the synthesis of 2-acyl indolines through Cobalt-catalyzed C-H activation/[3+2] annulation of aniline derivatives and acrylates. The method utilizes a cobalt catalyst to achieve high regioselectivity in the formation of functionalized 2-acylindolines. The mechanism is investigated through KIE experiments and deuterium-labeling experiment. The scalability and application value of the method is confirmed through gram-scale synthesis and synthetic transformations.
An approach for 2-acyl indolines synthesis through Cobalt-catalyzed C-H activation/[3+2] annulation of aniline derivatives and acrylates is described. The method employs cobalt catalyst to afford a wide variety of functionalized 2-acylindolines with high regioselectivity. The mechanism is investigated by KIE experiments and deuterium-labeling experiment. The gram-scale synthesis and synthetic transformations are also conducted, confirming the scalability and application value.
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