Journal
ADVANCED MATERIALS
Volume 35, Issue 11, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202209379
Keywords
immunotherapy; oncolytic viruses; prodrugs; pyroptosis; signal transducers and activators of transcription 3
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This study reports a combinational therapeutic strategy that combines tumor microenvironment-reactive oxygen species/pH dual-responsive signal transducers and activators of transcription 3 inhibitor nanoprodrugs with oncolytic herpes simplex virus 1 virotherapy to enhance immunotherapy. This strategy successfully activates robust T-cell-dependent antitumor responses, potentiating immune checkpoint blockade effects against local recurrence and pulmonary metastasis in preclinical cold murine triple-negative breast cancer and syngeneic oral cancer models.
Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (TME) are considered as the two major stumbling blocks to a broad ICB response. Here, a combinational therapeutic strategy is reported, wherein TME-reactive oxygen species/pH dual-responsive signal transducers and activators of transcription 3 inhibitor nanoprodrugs MPNPs are combined with oncolytic herpes simplex virus 1 virotherapy to synergistically ignite pyroptosis for enhancing immunotherapy. MPNPs exhibit a certain level of tumor accumulation, reduce tumor cell stemness, and enhance antitumor immune responses. Furthermore, the simultaneous application of oncolytic viruses (OVs) confers MPNPs with higher tumor penetration capacity and remarkable gasdermin-E-mediated pyroptosis, thereby reshaping the TME and transforming cold tumors into hot ones. This fire of immunity strategy successfully activates robust T-cell-dependent antitumor responses, potentiating ICB effects against local recurrence and pulmonary metastasis in preclinical cold murine triple-negative breast cancer and syngeneic oral cancer models. Collectively, this work may pave a new way and offer an unprecedented opportunity for the combination of OVs with nanomedicine for cancer immunotherapy.
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