Spatiotemporal On-Off Immunomodulatory Hydrogel Targeting NLRP3 Inflammasome for the Treatment of Biofilm-Infected Diabetic Wounds

Article Chemistry, Multidisciplinary

pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

Yongping Liang et al.

Summary: A dual-responsive hydrogel dressing was constructed for the treatment of type II diabetic foot ulcers and shown to promote wound healing in a rat model. The addition of metformin and graphene oxide further enhanced wound repair.

ACS NANO (2022)

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Article Engineering, Biomedical

Encountering and Wrestling: Neutrophils Recognize and Defensively Degrade Graphene Oxide

Shiyi Huang et al.

Summary: The study reveals the different defensive behaviors of neutrophils towards graphene oxide (GO) and their mechanisms, including NETosis induced by mGO and degranulation triggered by nGO, accompanied by the generation of reactive oxygen species and activation of p-ERK and p-Akt kinases. Moreover, MPO plays a determinant role in the different responses of neutrophils to GO.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

3D bioprinted GelMA/GO composite induces osteoblastic differentiation

Yerong Jiang et al.

Summary: This study proposes a strategy to generate a scaffold for bone regenerative repair by directly blending graphene oxide (GO) and mesenchymal stem cells (MSCs) with gelatin methacrylate anhydride (GelMA) as bioink. The introduction of GO positively influenced MSC proliferation and osteogenesis, enhancing cell proliferation and adhesion properties compared with pure GelMA.

JOURNAL OF BIOMATERIALS APPLICATIONS (2022)

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Review Public, Environmental & Occupational Health

Wound Chronicity, Impaired Immunity and Infection in Diabetic Patients

Nadia Rodriguez-Rodriguez et al.

Summary: Diabetic foot ulcers are a serious complication of diabetes that can lead to amputation, infection and premature death. Immune dysfunction in diabetic patients increases susceptibility to infection. Biofilm formation caused by infection worsens the prognosis of wounds.

MEDICC REVIEW (2022)

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Article Biotechnology & Applied Microbiology

An injectable photo-cross-linking silk hydrogel system augments diabetic wound healing in orthopaedic surgery through spatiotemporal immunomodulation

Jiawei Mei et al.

Summary: In this study, a photocurable hydrogel system was developed to enhance diabetic-wound healing through spatiotemporal immunomodulation. The system effectively resolved the immune contradiction in diabetic wounds by releasing drugs and silver nanoparticles, promoting tissue repair while inhibiting bacterial aggregation.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Endocrinology & Metabolism

Pyroptosis and inflammasomes in diabetic wound healing

Xingrui Mu et al.

Summary: Research has shown that pyroptosis plays an important role in diabetic wounds. Inflammation and activation of the inflammasome are closely related to the recovery of diabetic wounds. Studying new theories, approaches, and potential compounds targeting pyroptosis and inflammasome signaling pathways may provide new strategies for treating diabetic wounds.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Engineering, Biomedical

Injectable conductive gelatin methacrylate / oxidized dextran hydrogel encapsulating umbilical cord mesenchymal stem cells for myocardial infarction treatment

Shuoji Zhu et al.

Summary: The study found that using GelMA-O5/rGO hydrogel encapsulating UCMSCs could significantly improve damaged myocardial tissue and reconstruct myocardial function, which may be a promising therapeutic strategy for cardiac repair.

BIOACTIVE MATERIALS (2022)

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Article Polymer Science

Self-Gelling Solid Lipid Nanoparticle Hydrogel Containing Simvastatin as Suitable Wound Dressing: An Investigative Study

Bhumika Gupta et al.

Summary: In this study, a self-gelling solid lipid nanoparticle (SLN) dressing incorporating the lipophilic wound-healing agent simvastatin was developed. The SLN-hydrogel exhibited good mechanical properties, slow release, and improved wound healing in rat models. The novel hydrogel dressing shows promise for wound care applications.

GELS (2022)

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Article Materials Science, Biomaterials

An implantable smart hyperthermia nanofiber with switchable, controlled and sustained drug release: Possible application in prevention of cancer local recurrence

Shadi Samadzadeh et al.

Summary: Smart hyperthermia nanofibers with temperature-responsive heat generation and dual-stage drug release capability have been developed, showing improved hyperthermic chemotherapy efficiency through 'ON-OFF' switching of an alternating magnetic field. These nanofibers exhibited reversible swelling ratio and controllable drug discharge properties in response to the magnetic field, leading to enhanced cytotoxicity compared to standard chemotherapy regimens.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Nanoscience & Nanotechnology

Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation

Baojin Ma et al.

Summary: The reaction between graphene oxide and glutathione affects the intracellular redox balance, increasing reactive oxygen species levels and inhibiting cell viability and proliferation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Strategy for Treatment of Infected Diabetic Foot Ulcers

Mayland Chang et al.

Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Article Environmental Sciences

Combined effects of Pseudomonas quinolone signal-based quorum quenching and graphene oxide on the mitigation of biofouling and improvement of the application potential for the thin-film composite membrane

Yuan Li et al.

Summary: The study investigated the combined effects of graphene oxide modification and methyl anthranilate addition on biofouling mitigation in thin-film composite membranes. Results showed that the TFN-S membrane with MA addition exhibited superior anti-biofouling performance based on the combined effects of GO and MA, reducing flux decline and EPS secretion. Furthermore, exogenous addition of MA led to a relatively loose biofilm structure, resulting in high membrane permeability in the biofouling formation process.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Review Chemistry, Multidisciplinary

Engineering Hydrogel-Based Biomedical Photonics: Design, Fabrication, and Applications

Carlos F. Guimaraes et al.

Summary: Light guiding and manipulation in photonics play a crucial role in various fields, offering advantages in biomedical optics, data transmission, photomedicine, and detecting multi-scale phenomena. Hydrogels have emerged as promising materials that combine light-guiding properties with live tissue compatibility, showcasing potential in photonics and bioengineering.

ADVANCED MATERIALS (2021)

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Review Pharmacology & Pharmacy

Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory

Kang Geng et al.

Summary: Recent studies have shown that the interaction between immune and metabolic responses is crucial for maintaining tissue and organ homeostasis, playing a significant role in the development of chronic diseases. In diabetic wound healing, the abnormal activation of innate immune cells is essential in triggering and sustaining inflammation. Targeting these innate immune pathways and reprogramming immune cell phenotypes show great potential in diabetic wound therapy.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome

Yan Zhao et al.

Summary: Bletilla striata polysaccharide accelerates diabetic wound healing, suppresses macrophage infiltration, promotes angiogenesis, inhibits NLRP3 inflammasome activation, and improves insulin sensitivity in wound tissues in diabetic mice. It also protects against high glucose-induced ROS generation and NLRP3 inflammasome activation in vitro, while improving cell viability and insulin sensitivity.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Patchouli alcohol improves wound healing in high fat diet-fed mice through AMPK-mediated suppression of inflammation and TGFb1 signaling

Tae Jin Kim et al.

Summary: The study found that patchouli alcohol can promote wound healing and improve inflammation in high fat diet-fed mice by enhancing AMP-activated protein kinase (AMPK) phosphorylation and TGFb1 expression. In addition, PA accelerates wound healing by promoting cell migration and suppressing inflammation.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Review Immunology

NLRP3 inflammasome activation and cell death

Yi Huang et al.

Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Immunology

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Hongxu Xian et al.

Summary: The study found that metformin can attenuate COVID-19-induced ARDS by inhibiting NLRP3 inflammasome activation, IL-1 beta and IL-6 secretion, and by blocking ATP and mtDNA synthesis.

IMMUNITY (2021)

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Review Immunology

Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes

Maedeh Arabpour et al.

Summary: MSC-derived exosomes have the potential to polarize M2 macrophages and modulate inflammation in various diseases and conditions like CNS diseases, autoimmune diseases, inflammatory bowel disease, and cardiomyopathy.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Prolonged proliferation and delayed senescence of the adipose-derived stem cells grown on the electrospun composite nanofiber co-encapsulated with TiO2 nanoparticles and metformin-loaded mesoporous silica nanoparticles

Raheleh Pourpirali et al.

Summary: This study demonstrates that the nanofibers coencapsulated with nTiO2 and MET@MSNs can prolong the in vitro expansion of human adipose-derived stem cells without inducing cellular senescence and aging. The platform enhances adhesion, metabolic activity, and proliferation rate of the cells, and leads to the upregulation of autophagy and stemness markers as well as the down-regulation of senescence marker. Moreover, it results in increased telomere length and telomerase activity in the cells cultured on the nanofibers compared to other types.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Biochemistry & Molecular Biology

Skin Wound Healing: Normal Macrophage Function and Macrophage Dysfunction in Diabetic Wounds

Savannah M. Aitcheson et al.

Summary: Macrophages play a crucial role in wound healing, but in individuals with diabetes, these cells are dysfunctional, hindering the healing process and potentially leading to the formation of diabetic foot ulcers. Understanding macrophage dysregulation in DFUs and developing better therapies can improve healing rates in these patients.

MOLECULES (2021)

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Article Multidisciplinary Sciences

A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Guodong Li et al.

Summary: This study reports the design and synthesis of a small molecule stabilizer of HIF-1 alpha, which promotes wound healing in diabetic patients according to experiments in mouse models. The compound accelerates wound closure in both normal and diabetic mice, with a greater effect observed in diabetic mice, indicating its potential as a therapeutic agent for diabetic wounds.

NATURE COMMUNICATIONS (2021)

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Article Cell & Tissue Engineering

PHAGOCYTOSIS AND MACROPHAGE POLARISATION ON BACTERIALLY CONTAMINATED DENTAL IMPLANT MATERIALS AND EFFECTS ON TISSUE INTEGRATION

Y. Yuan et al.

Summary: Macrophages play a crucial role in clearing bacterial contamination and promoting tissue coverage on dental implant surfaces. The polarization of macrophages can influence the effectiveness of bacteria clearance and tissue integration on different types of dental implant materials.

EUROPEAN CELLS & MATERIALS (2021)

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The Antibacterial Effect of Graphene Oxide on Streptococcus mutans

Manduo Zhao et al.

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Extracellular vesicles for acute kidney injury in preclinical rodent models: a meta-analysis

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Staphylococci evade the innate immune response by disarming neutrophils and forming biofilms

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Quorum Sensing Communication: Molecularly Connecting Cells, Their Neighbors, and Even Devices

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Graphene Oxide Nanoribbon Hydrogel: Viscoelastic Behavior and Use as a Molecular Separation Membrane

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MFG-E8 accelerates wound healing in diabetes by regulating NLRP3 inflammasome-neutrophil extracellular traps axis

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Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway

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Functionalized graphene oxide as a vehicle for targeted drug delivery and bioimaging applications

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Biocompatible graphene-based nanoagent with NIR and magnetism dual-responses for effective bacterial killing and removal

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Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion

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Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages

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Cytokine Profiling of Primary Human Macrophages Exposed to Endotoxin-Free Graphene Oxide: Size-Independent NLRP3 Inflammasome Activation

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The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

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Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLR family pyrin domain containing 3 (NLRP3) inflammasome in diabetic rats

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Spatiotemporal On-Off Immunomodulatory Hydrogel Targeting NLRP3 Inflammasome for the Treatment of Biofilm-Infected Diabetic Wounds

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