Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 33, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202209658
Keywords
electrical stimulations; magnetic stimulations; morphology guiding; peripheral nerve regeneration; physiotherapy; ultrasound stimulations
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Physical cue-based strategies have shown promising potential for the treatment of peripheral nerve injuries, serving as stimulators for cell functions and morphology, and enabling low-invasive, wireless, and battery-free neuromodulation.
Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine. Recently, physical cue-based strategies (e.g., electrical neurostimulation, acoustic radiation, electromagnetic bioregulation, as well as directional fiber guiding, etc.) have drawn increasing attention not only as a stimulator for cell functions modulation and fate determination, but also as a morphology-index for modulating cell phenotype, proliferation, and differentiation, especially for nerve cells. More importantly, the advanced percutaneous power transmission technology, self-power nanotechnology that leverages piezoelectrical/triboelectricity materials, and focused ultrasound and pulsed electromagnetic field technology exhibit the appealing practice potential for achieving low-invasive, wireless, and battery-free neuromodulation. In this review, recent advances of physical cue-based strategies including electrical, acoustic, magnetic, and morphology for PNI are systematically overviewed, and the open challenges for realizing scalable clinical/commercial transformation and future perspectives of these strategies for PNI are concluded.
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