Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 192, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2022.114638
Keywords
Ultrasmall nanotechnology; Silica nanomaterials; Nano-bio interactions; Clearance; Cancer nanomedicine; Clinical translation; Contents
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This review discusses the application of ultrasmall silica nanoparticles (USNs) in biomedical research, with a focus on their potential in diagnostics, therapy, and drug delivery. The review summarizes synthetic strategies for USNs, including control over size and surface chemistry, functionalization, and pharmacokinetic and toxicological profiles. Additionally, the review highlights challenges in the translation of inorganic nanotechnology and proposes potential solutions and future opportunities for accelerating the widespread adoption of USN technology in biomedical research.
The exemplary progress of silica nanotechnology has attracted extensive attention across a range of biomedical applications such as diagnostics and imaging, drug delivery, and therapy of cancer and other diseases. Ultrasmall silica nanoparticles (USNs) have emerged as a particularly promising class demonstrating unique properties that are especially suitable for and have shown great promise in translational and clinical biomedical research. In this review, we discuss synthetic strategies that allow precise engineering of USNs with excellent control over size and surface chemistry, functionalization, and pharmacokinetic and toxicological profiles. We summarize the current state-of-the-art in the biomedical applications of USNs with a particular focus on select clinical studies. Finally, we illustrate longstanding challenges in the translation of inorganic nanotechnology, particularly in the context of ultrasmall nanomedicines, and provide our perspectives on potential solutions and future opportunities in accelerating the translation and widespread adoption of USN technology in biomedical research.(c) 2022 Elsevier B.V. All rights reserved.
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