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Biophysical heterogeneity of myeloid-derived microenvironment to regulate resistance to cancer immunotherapy

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Summary: This article reviews recent advances in the field of two-photon fluorescent nanomaterials, highlighting their applications in biomedical field such as biosensing, imaging, and therapy. It introduces the optical properties, synthetic methods, and important applications of TPE nanomaterials including organic molecules, quantum dots, carbon dots, and metal nanoclusters. The challenges and future prospects in the development of two-photon fluorescent nanomaterials are also discussed.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages

Aleksandar Obradovic et al.

Summary: This study identified specific subpopulations and their master regulators through single-cell RNA sequencing, and found that TREM2/APOE/C1Q-positive macrophage infiltration could serve as a potential prognostic biomarker for ccRCC recurrence.

CELL (2021)

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Article Multidisciplinary Sciences

Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme

Jiemiao Hu et al.

Summary: The overexpression of CXCL1 and CXCL2 is closely associated with the aggressiveness of GBM, and blocking these molecules can slow down tumor progression and increase patient survival rates.

SCIENCE ADVANCES (2021)

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Article Gastroenterology & Hepatology

Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma

Man Liu et al.

GUT (2020)

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Review Immunology

Top 10 Challenges in Cancer Immunotherapy

Priti S. Hegde et al.

IMMUNITY (2020)

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Article Medicine, Research & Experimental

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils

Karim Mahiddine et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Immunology

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

Anders Etzerodt et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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In Vivo Monocyte/Macrophage-Hitchhiked Intratumoral Accumulation of Nanomedicines for Enhanced Tumor Therapy

Liyan Zheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Biochemistry & Molecular Biology

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Hui Yang et al.

MOLECULAR CANCER (2020)

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Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Zhihao Lu et al.

NATURE (2020)

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Single-cell RNA-seq clustering: datasets, models, and algorithms

Lihong Peng et al.

RNA BIOLOGY (2020)

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Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Jesse M. Jaynes et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

Yuya Terashima et al.

NATURE COMMUNICATIONS (2020)

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Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

Yang Li et al.

NATURE COMMUNICATIONS (2020)

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Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

Hamad Alshetaiwi et al.

SCIENCE IMMUNOLOGY (2020)

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Computational Modelling of the Bioheat Transfer Process in Human Skin Subjected to Direct Heating and/or Cooling Sources: A Systematic Review

Mariana Silva et al.

ANNALS OF BIOMEDICAL ENGINEERING (2020)

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Article Pharmacology & Pharmacy

Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours

Devalingam Mahalingam et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression

Samir Devalaraja et al.

CELL (2020)

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Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang et al.

CELL (2020)

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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

Alvaro Teijeira et al.

IMMUNITY (2020)

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Review Immunology

The CD47-SIRPα Immune Checkpoint

Meike E. W. Logtenberg et al.

IMMUNITY (2020)

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A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy

Balamayoora Theivanthiran et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases

Lin Zhang et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Control of brain tumor growth by reactivating myeloid cells with niacin

Susobhan Sarkar et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Carbon Nanomaterials Promote M1/M2 Macrophage Activation

Pia Anneli Sofia Kinaret et al.

SMALL (2020)

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High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation

Wei He et al.

NATURE COMMUNICATIONS (2020)

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Effective combinatorial immunotherapy for penile squamous cell carcinoma

Tianhe Huang et al.

NATURE COMMUNICATIONS (2020)

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Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

Nayoung Kim et al.

NATURE COMMUNICATIONS (2020)

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Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment, in PTEN-Deficient Prostate Cancer

Di Zhao et al.

CANCER DISCOVERY (2020)

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Application of magnetic nanoparticles in nucleic acid detection

Congli Tang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Human chimeric antigen receptor macrophages for cancer immunotherapy

Michael Klichinsky et al.

NATURE BIOTECHNOLOGY (2020)

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PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

Brian Diskin et al.

NATURE IMMUNOLOGY (2020)

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BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

Bruno Bockorny et al.

NATURE MEDICINE (2020)

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Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

Yonatan Katzenelenbogen et al.

CELL (2020)

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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora et al.

CELL (2020)

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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Junbin Qian et al.

CELL RESEARCH (2020)

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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

Min-Hee Oh et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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A Smart Nanoparticle-Laden and Remote-Controlled Self-Destructive Macrophage for Enhanced Chemo/Chemodynamic Synergistic Therapy

Panpan Sun et al.

ACS NANO (2020)

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DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Linbin Yang et al.

NATURE (2020)

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Disabled Homolog 2 Controls Prometastatic Activity of Tumor- Associated Macrophages

Ilaria Marigo et al.

CANCER DISCOVERY (2020)

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Endogenous Glucocorticoid Signaling Regulates CD8+T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Nandini Acharya et al.

IMMUNITY (2020)

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The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses

Isabelle C. Arnold et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis

Peishan Li et al.

NATURE IMMUNOLOGY (2020)

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Tackling TAMs for Cancer Immunotherapy: It's Nano Time

Yishun Yang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

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Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion

Bianca Cioni et al.

NATURE COMMUNICATIONS (2020)

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Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

Astrid De Boeck et al.

NATURE COMMUNICATIONS (2020)

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A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Donghai Xiong et al.

NATURE COMMUNICATIONS (2020)

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Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

Michela Perego et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway

Mimi Chen et al.

BIOACTIVE MATERIALS (2020)

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In Vivo Self-Assembly Based Cancer Therapy Strategy

Jinrong Chen et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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Advances in Aptamer Screening and Drug Delivery

Yujie Tang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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CANCER Physical traits of cancer

Hadi T. Nia et al.

SCIENCE (2020)

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Zeptosecond birth time delay in molecular photoionization

Sven Grundmann et al.

SCIENCE (2020)

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Enhancing cancer immunotherapy with nanomedicine

Darrell J. Irvine et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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CCL15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma

Long-Zi Liu et al.

HEPATOLOGY (2019)

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Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer

Ping Zhou et al.

BIOMATERIALS (2019)

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Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

Luca Cassetta et al.

CANCER CELL (2019)

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Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

Ying Zhu et al.

GUT (2019)

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Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer

Qinchuan Wu et al.

HEPATOLOGY (2019)

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Targeting Stroma: A Tale of Caution

Andrea Wang-Gillam

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma

Jing Liu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

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The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer

Jong Woo Lee et al.

JOURNAL OF THORACIC ONCOLOGY (2019)

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Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

Clemence Hollande et al.

NATURE IMMUNOLOGY (2019)

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Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

Ann-Christin Frank et al.

NATURE COMMUNICATIONS (2019)

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Specialized dendritic cells induce tumor-promoting IL-10+IL-17+ FoxP3neg regulatory CD4+ T cells in pancreatic carcinoma

Rocky M. Barilla et al.

NATURE COMMUNICATIONS (2019)

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Therapeutic Remodeling of the Tumor Microenvironment Enhances Nanoparticle Delivery

Yuanxin Chen et al.

ADVANCED SCIENCE (2019)

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Collagen density regulates the activity of tumor-infiltrating T cells

Dorota E. Kuczek et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Receptor-Interacting Protein Kinase 3 Deficiency Recruits Myeloid-Derived Suppressor Cells to Hepatocellular Carcinoma Through the Chemokine (C-X-C Motif) Ligand 1-Chemokine (C-X-C Motif) Receptor 2 Axis

Yi-Ming Li et al.

HEPATOLOGY (2019)

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A Positive Feedback Loop Between Cancer Stem-Like Cells and Tumor-Associated Neutrophils Controls Hepatocellular Carcinoma Progression

Shao-Lai Zhou et al.

HEPATOLOGY (2019)

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Nuclear positioning facilitates amoeboid migration along the path of least resistance

Joerg Renkawitz et al.

NATURE (2019)

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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Maisa C. Takenaka et al.

NATURE NEUROSCIENCE (2019)

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Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer A Phase 2 Clinical Trial

Janet E. Murphy et al.

JAMA ONCOLOGY (2019)

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Review Chemistry, Multidisciplinary

Near-Infrared Photoimmunotherapy of Cancer

Hisataka Kobayashi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Junya Peng et al.

CELL RESEARCH (2019)

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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

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Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma

Victor Maximov et al.

NATURE COMMUNICATIONS (2019)

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Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming

Mautin Hundeyin et al.

CANCER DISCOVERY (2019)

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Granulocytic Myeloid-Derived Suppressor Cells Promote the Stemness of Colorectal Cancer Cells through Exosomal S100A9

Yungang Wang et al.

ADVANCED SCIENCE (2019)

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The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial

Donald T. Weed et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer

Pawel Bieniasz-Krzywiec et al.

CELL METABOLISM (2019)

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Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

Ik Sun Kim et al.

NATURE CELL BIOLOGY (2019)

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Tumor-Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel-Enhanced Immunotherapy with Polarization toward M1-Type Macrophages on Triple Negative Breast Cancers

Lv Chen et al.

ADVANCED MATERIALS (2019)

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Article Biochemistry & Molecular Biology

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

Qiming Zhang et al.

CELL (2019)

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Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer

Qingfei Wang et al.

NATURE COMMUNICATIONS (2019)

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Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Yu-Kuan Huang et al.

NATURE COMMUNICATIONS (2019)

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Tumor-Associated Macrophages in Hematologic Malignancies: New Insights and Targeted Therapies

Amy J. Petty et al.

CELLS (2019)

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Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue

Yu Si et al.

SCIENCE IMMUNOLOGY (2019)

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Tumor-associated Macrophage-derived Interleukin-23 Interlinks Kidney Cancer Glutamine Addiction with Immune Evasion

Qiang Fu et al.

EUROPEAN UROLOGY (2019)

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Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

Jun Wei et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis

Brett L. Ecker et al.

CANCER DISCOVERY (2019)

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Material stiffness influences the polarization state, function and migration mode of macrophages

Rukmani Sridharan et al.

ACTA BIOMATERIALIA (2019)

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Association of MMP9-1562C/T and MMP13-77A/G Polymorphisms with Non-Small Cell Lung Cancer in Southern Chinese Population

Wen Li et al.

BIOMOLECULES (2019)

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Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

Timothy M. Nywening et al.

GUT (2018)

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Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-Small Cell Lung Cancer

Yoshikane Yamauchi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

Wei Li et al.

CELL METABOLISM (2018)

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Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice

Chongbiao Huang et al.

GASTROENTEROLOGY (2018)

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Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells

Jing Li et al.

IMMUNITY (2018)

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Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

Eric Ubil et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

Neha N. Parayath et al.

NANO LETTERS (2018)

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Remodeling the Tumor Microenvironment with Emerging Nanotherapeutics

Qin Chen et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

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Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

Melissa A. Meyer et al.

NATURE COMMUNICATIONS (2018)

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Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

Mana Taki et al.

NATURE COMMUNICATIONS (2018)

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Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Alessandro Porrello et al.

NATURE COMMUNICATIONS (2018)

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Correction Multidisciplinary Sciences

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype (vol 9, 873, 2018)

Degao Chen et al.

NATURE COMMUNICATIONS (2018)

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Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours

Adama Sidibe et al.

NATURE COMMUNICATIONS (2018)

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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2 alpha

Qirui Wang et al.

NATURE COMMUNICATIONS (2018)

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Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Tomer Cooks et al.

NATURE COMMUNICATIONS (2018)

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Cytokine Networks between innate Lymphoid Cells and Myeloid Cells

Arthur Mortha et al.

FRONTIERS IN IMMUNOLOGY (2018)

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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

Christopher B. Rodell et al.

NATURE BIOMEDICAL ENGINEERING (2018)

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M1 Macrophage-Derived Nanovesicles Potentiate the Anticancer Efficacy of Immune Checkpoint Inhibitors

Yeon Woong Choo et al.

ACS NANO (2018)

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LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

Larissa D. Cunha et al.

CELL (2018)

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Macrophages of distinct origins contribute to tumor development in the lung

Pierre-Louis Loyher et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

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Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Chih-Chan Lee et al.

NATURE COMMUNICATIONS (2018)

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Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery

Weizhong Zhang et al.

ADVANCED MATERIALS (2018)

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Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

Veronica Huber et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

Hui-Ming Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer

Sushil Kumar et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo

Deby F. Mardhian et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis

Minoru Inoue et al.

NATURE COMMUNICATIONS (2018)

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Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

Zhi-Fa Wen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Improving immune-vascular crosstalk for cancer immunotherapy

Yuhui Huang et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

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Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy

Amira A. Barkal et al.

NATURE IMMUNOLOGY (2018)

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Combining vasculature disrupting agent and toll-like receptor 7/8 agonist for cancer therapy

Anushree Seth et al.

ONCOTARGET (2017)

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Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

Ting-ting Wang et al.

GUT (2017)

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Neutrophils Promote Hepatic Metastasis Growth Through Fibroblast Growth Factor 2-Dependent Angiogenesis in Mice

Alex N. Gordon-Weeks et al.

HEPATOLOGY (2017)

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Of Human DC Migrants and Residents

Elodie Segura et al.

IMMUNITY (2017)

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Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

Yu Zhu et al.

IMMUNITY (2017)

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Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life

Tomer Granot et al.

IMMUNITY (2017)

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NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development

Nivedita M. Ratnam et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β

Benjamin Weichand et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Biochemistry & Molecular Biology

An ESIPT-based two-photon fluorescent probe detection of hydrogen peroxide in live cells and tissues

Liyi Zhou et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2017)

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Effective combinatorial immunotherapy for castration-resistant prostate cancer

Xin Lu et al.

NATURE (2017)

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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Sydney R. Gordon et al.

NATURE (2017)

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VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

Jianjun Gao et al.

NATURE MEDICINE (2017)

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In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

Sean P. Arlauckas et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Maria Ouzounova et al.

NATURE COMMUNICATIONS (2017)

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Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

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