☆ 4.8 Article

Carrier-free subunit nanovaccine amplifies immune responses against tumors and viral infections

ACTA BIOMATERIALIA (2023)

Related references

Note: Only part of the references are listed.

Article Engineering, Biomedical

Antigen epitope-TLR7/8a conjugate as self-assembled carrier-free nanovaccine for personalized immunotherapy

Huijuan Song et al.

Summary: An epitope-based vaccine platform has been developed, which self-assembles into nanostructures without the use of additional carriers. It effectively introduces antigen and adjuvant, enhances dendritic cell activation and T-cell immunity, and shows potential therapeutic effects.

ACTA BIOMATERIALIA (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Self-degradable poly(β-amino ester)s promote endosomal escape of antigen and agonist

Hong Liu et al.

Summary: Vaccination with subunit nanovaccines loaded with STING agonists and subunit antigens shows promising results in combating virus infection and tumor development. The nanovaccine exhibited strong immunogenicity, remodeled the tumor microenvironment, and inhibited tumor progression, increasing the survival rates of animals.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Review Materials Science, Multidisciplinary

Carrier-free nanomedicines for cancer treatment

Li-Han Liu et al.

Summary: The past decade has seen significant advances in the development of carrier-free nanomedicines, which are attractive due to their high biosafety, drug loading capacities, simple compositions, and simplified synthesis procedures. Extensive efforts have been made to expand the scope of carrier-free nanomedicines and improve their therapeutic performance through the exploration of new excipients, therapeutic agents, self-assembly methods, and mechanisms. This review summarizes the research progress and practical applications of carrier-free nanomedicines in cancer therapy.

PROGRESS IN MATERIALS SCIENCE (2022)

Add to Collection

Review Engineering, Multidisciplinary

Fabrication of subunit nanovaccines by physical interaction

HaoLin Chen et al.

Summary: Vaccines can improve human life by preventing infectious diseases and can also be used for tumor prevention and treatment. Subunit vaccines, which have antigens in the form of proteins or peptides, offer safety to recipients but have relatively low immunogenicity. Nanoparticular delivery systems and molecular adjuvants can enhance the immunocompetence of subunit vaccines.

SCIENCE CHINA-TECHNOLOGICAL SCIENCES (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Nanoadjuvants Actively targeting lymph node conduits and blocking tumor invasion in lymphatic vessels

Hong Liu et al.

Summary: This study demonstrates the potential of modified nanoparticles to target lymph nodes and enhance immune responses for cancer therapy.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Review Pharmacology & Pharmacy

Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors

Tong Ye et al.

Summary: Personalized cancer vaccines have gained attention for their ability to overcome interindividual differences and show benefits for individual patients in the clinic. Various delivery vectors, including artificial materials, engineered microorganisms, cells and cell derivatives, have been studied to enhance the therapeutic performance of personalized cancer vaccines. These delivery vectors are utilized to improve antigen distribution and immune response strength, velocity, and duration through different delivery strategies.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Review Pharmacology & Pharmacy

Immunological perspectives on spatial and temporal vaccine delivery

Mingzhao Zhu

Summary: Rational vaccine design is considered an important direction in research and development, with lymph node targeting being a popular strategy for enhancing vaccine efficacy. In addition to LN targeting, cellular targeting and even subcellular compartment targeting should be considered to optimize immune response.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Article Engineering, Biomedical

Engineered therapeutic nanovaccine against chronic hepatitis B virus infection

Dongdong Qiao et al.

Summary: Nanovaccines prepared using flash nanocomplexation technology enhance the uptake of antigens and adjuvants by cells, promote the maturation and activation of dendritic cells, and exhibit excellent lymph nodes targeting ability. Co-administered nanovaccines can break immune tolerance, restore HBV-specific immune responses, and achieve high rates of seroclearance and seroconversion in a mouse model of CHB. The vaccines also induce long-term immune memory to protect against HBV reinfection.

BIOMATERIALS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Nanotechnology for virus treatment

Jiarong Zhou et al.

Summary: The emergence of novel viruses poses a significant threat to global health, with nanotechnology offering potential solutions to overcome challenges in antiviral therapies. Nanotechnology can improve drug absorption and reduce toxicity, as well as utilize unique nanomaterials for virus inactivation. By researching the latest developments in antiviral nanotherapeutics, new solutions can be provided for future virus pandemics.

NANO TODAY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine

Dan Liu et al.

Summary: Nanovaccines incorporating two adjuvants and antigens were efficiently constructed, overcoming obstacles in traditional vaccine preparation and enhancing immune responses. The selected adjuvants achieved a notable immune response through synergistic activation of signaling pathways, significantly inhibiting tumor growth and prolonging the survival time of mice.

NANO LETTERS (2021)

Add to Collection

Article Chemistry, Medicinal

3D Interaction Homology: Hydropathic Analyses of the π-Cation and π-π Interaction Motifs in Phenylalanine, Tyrosine, and Tryptophan Residues

Mohammed H. Al Mughram et al.

Summary: This study focuses on the aromatic residues phenylalanine, tyrosine, and tryptophan in protein structures, analyzing their interactions with the environment through 3D maps. It was found that highly buried side chains are encapsulated by hydrophobic interactions, while solvent-exposed side chains are more likely to engage in polar interactions. The research also shows evidence of pi-pi and pi-cation interactions in these residues, contributing to a small percentage of the total energy in the structural roles of these residues.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)

Add to Collection

Review Immunology

Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Lantian Lu et al.

Summary: This article discusses the use of covalent conjugation strategies to graft protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines, and the advantages of chemical conjugation in developing these vaccines.

VACCINES (2021)

Add to Collection

Review Engineering, Biomedical

Advancements in prophylactic and therapeutic nanovaccines

Prateek Bhardwaj et al.

ACTA BIOMATERIALIA (2020)

Add to Collection

Article Chemistry, Physical

Reverse immune suppressive microenvironment in tumor draining lymph nodes to enhance anti-PD1 immunotherapy via nanovaccine complexed microneedle

Zhongzheng Zhou et al.

NANO RESEARCH (2020)

Add to Collection

Editorial Material Biotechnology & Applied Microbiology

The COVID-19 vaccine development landscape

Tung Thanh Le et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Add to Collection

Review Immunology

Better Adjuvants for Better Vaccines: Progress in Adjuvant Delivery Systems, Modifications, and Adjuvant-Antigen Codelivery

Zhi-Biao Wang et al.

VACCINES (2020)

Add to Collection

Article Engineering, Biomedical

Therapeutic nanovaccines sensitize EBV-associated tumors to checkpoint blockade therapy

Hong Liu et al.

BIOMATERIALS (2020)

Add to Collection

Review Immunology

Emerging advances in synthetic cancer nano-vaccines: opportunities and challenges

Mohammad Zaki Ahmad et al.

EXPERT REVIEW OF VACCINES (2020)

Add to Collection

Review Cell Biology

PD-1/PD-L1 pathway: Basic biology and role in cancer immunotherapy

Arash Salmaninejad et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection

Review Immunology

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

Shuting Shi et al.

VACCINE (2019)

Add to Collection

Review Engineering, Biomedical

Nano-, micro-, and macroscale drug delivery systems for cancer immunotherapy

Pingsheng Huang et al.

ACTA BIOMATERIALIA (2019)

Add to Collection

Article Materials Science, Biomaterials

A surface charge dependent enhanced Th1 antigen-specific immune response in lymph nodes by transfersome-based nanovaccine-loaded dissolving microneedle-assisted transdermal immunization

Xuanjin Wu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Potency of a Scalable Nanoparticulate Subunit Vaccine

Dongdong Qiao et al.

NANO LETTERS (2018)

Add to Collection

Article Multidisciplinary Sciences

Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice

Ying Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Nanoparticles for Immune Stimulation Against Infection, Cancer, and Autoimmunity

Santiswarup Singha et al.

ACS NANO (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists

Matthew D. Morin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection

Review Biotechnology & Applied Microbiology

The π-π stacking-guided supramolecular self-assembly of nanomedicine for effective delivery of antineoplastic therapies

Dongjuan Yang et al.

NANOMEDICINE (2018)

Add to Collection

Review Immunology

Nanoparticle Vaccines Against Infectious Diseases

Rashmirekha Pati et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Lymph node targeting strategies to improve vaccination efficacy

Hao Jiang et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Synthetic nanovaccines for immunotherapy

Min Luo et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection

Article Immunology

Immunogenicity and Safety of the HZ/su Adjuvanted Herpes Zoster Subunit Vaccine in Adults Previously Vaccinated With a Live Attenuated Herpes Zoster Vaccine

Katrijn Grupping et al.

JOURNAL OF INFECTIOUS DISEASES (2017)

Add to Collection

Article Multidisciplinary Sciences

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice

Janet Lau et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Engineering, Biomedical

Drug self-delivery systems for cancer therapy

Si-Yong Qin et al.

BIOMATERIALS (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Substituent Effects in Parallel- Displaced π-π Stacking Interactions: Distance Matters

Leslie-Joana Riwar et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection

Review Medicine, Research & Experimental

Beyond antigens and adjuvants: formulating future vaccines

Tyson J. Moyer et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Add to Collection

Review Chemistry, Multidisciplinary

Current applications of nanoparticles in infectious diseases

Hinojal Zazo et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection

Review Pharmacology & Pharmacy

Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators

Signe Tandrup Schmidt et al.

PHARMACEUTICS (2016)

Add to Collection

Review Biotechnology & Applied Microbiology

Engineering nanoparticles to overcome barriers to immunotherapy

Randall Toy et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2016)

Add to Collection

Review Biotechnology & Applied Microbiology

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity

Natalie L. Trevaskis et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Add to Collection

Review Immunology

Nanoparticle Drug Delivery Systems Designed to Improve Cancer Vaccines and Immunotherapy

Yuchen Fan et al.

VACCINES (2015)

Add to Collection

Review Chemistry, Multidisciplinary

Immune system targeting by biodegradable nanoparticles for cancer vaccines

Joana M. Silva et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Add to Collection

Review Pharmacology & Pharmacy

Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine

Xue-Qing Zhang et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Add to Collection

Review Immunology

Use of defined TLR ligands as adjuvants within human vaccines

Malcolm S. Duthie et al.

IMMUNOLOGICAL REVIEWS (2011)

Add to Collection

Article Immunology

Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal vaccination

Suzanne M. Bal et al.

VACCINE (2011)

Add to Collection

Review Immunology

TLR-based immune adjuvants

Folkert Steinhagen et al.

VACCINE (2011)

Add to Collection

Review Immunology

Toll-like receptors and innate immunity

R Medzhitov

NATURE REVIEWS IMMUNOLOGY (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.