Journal
ACS NANO
Volume 17, Issue 3, Pages 2039-2052Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c07295
Keywords
gold nanoparticle; enhanced permeation and retention effect; mesenchymal stem cell; subcutaneous tumor; lung metastasis tumor
Ask authors/readers for more resources
There are gaps in knowledge regarding targeted delivery of nanoparticle-loaded cells in cancer nanotheranostics. This study compared the tumor targeting efficiency of gold nanoparticles delivered using either plain nanoparticles or human bone marrow mesenchymal stem cells (MSCs) loaded with endocytosed nanoparticles. The results showed that MSC-mediated delivery improved Au NP retention and tumor penetration compared to EPR-mediated delivery, although the absolute tumor retention of Au NPs remained low.
There are still some gaps in existing knowledge in the field of cancer nanotheranostics, e.g., the efficiency of nanoparticle-loaded cells for targeted delivery. In the current study, gold nanoparticles (Au NPs) were delivered to tumors in both subcutaneous tumor and lung metastasis tumor models by intravenous injection of either free Au NPs or of human bone marrow mesenchymal stem cells (MSCs), which were loaded with endocytosed Au NPs. By making injections with the same dose of administrated Au NPs, it was possible to directly compare tumor targeting of both delivery modes. Hereby, the passive targeting of tumor by the plain Au NPs was facilitated by the enhanced permeation and retention (EPR) effect. Au NP retention by tumors, as well as tumor penetration, were found to be improved up to 2.4-to-9.3-fold when comparing the MSC-mediated delivery of Au NPs to the delivery of the plain Au NPs via EPR effect on day 7 post administration. While the absolute retention of Au NPs in the tumor remained low, our data show that, upon injection of the same amount of Au NPs, in fact MSC-mediated delivery is quantitatively higher than EPR-mediated delivery of NPs by half an order of magnitude.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available