Injectable Drug Delivery Systems for Osteoarthritis and Rheumatoid Arthritis

Article Chemistry, Multidisciplinary

Biomimetic Hybrid Membrane-Coated Xuetongsu Assisted with Laser Irradiation for Efficient Rheumatoid Arthritis Therapy

Huanghe Yu et al.

Summary: The development of multifunctional nanoparticles utilizing nanotechnology for targeted treatment of rheumatoid arthritis has shown promising results in vivo, effectively inhibiting the progression of arthritis.

ACS NANO (2022)

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Article Nanoscience & Nanotechnology

Extracellular vesicle glucose transporter-1 and glycan features in monocyte-endothelial inflammatory interactions

Man Yang et al.

Summary: This study demonstrates that extracellular vesicles derived from endotoxin-stimulated monocytes activate inflammatory pathways in endothelial cells, partially mediated by GLUT-1. Alterations in glycan features were also observed in these vesicles.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

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Article Pharmacology & Pharmacy

Effects of Adipose-Derived Biogenic Nanoparticle-Associated microRNA-451a on Toll-like Receptor 4-Induced Cytokines

Xinghua Wang et al.

Summary: Extracellular vesicles (EVs) are nanoparticles released by cells that transfer biomolecules between cells. MicroRNAs (miRNAs/miRs) in EVs play a significant role in modulating signaling pathways in recipient cells. This study shows that miR-451a, abundant in EVs from adipose tissue, can suppress pro-inflammatory cytokines and enhance anti-inflammatory cytokines in the TLR4 pathway.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Injectable polymeric nanoparticle hydrogel system for long-term anti-inflammatory effect to treat osteoarthritis

Bo-Bae Seo et al.

Summary: In this study, an injectable anti-OA drug depot system for sustained drug release was developed. The system showed long-term effective therapeutic advantages in reducing pain and cartilage degeneration, and exhibited a significant inhibitory effect against further OA progression.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Physical

Albumin mediated reactive oxygen species scavenging and targeted delivery of methotrexate for rheumatoid arthritis therapy

Jing Zhong et al.

Summary: The study introduces a drug-induced self-assembly strategy for treating rheumatoid arthritis, demonstrating the therapeutic efficacy of HSA-SOD-MTX nanoparticles in a mouse model through the synergistic action of SOD enzyme and MTX drug.

NANO RESEARCH (2022)

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Review Chemistry, Medicinal

Knee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems

Luoyang Ma et al.

Summary: Drug delivery for osteoarthritis (OA) treatment is a persistent challenge due to low bioavailability and rapid clearance of drugs in the joints. Intra-articular (IA) drug delivery, as a common strategy, largely relies on the effectiveness of the drug-delivery system used for treating OA.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

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Article Cell Biology

Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays

Sara Busatto et al.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Orthopedics

Synovial fluid profile dictates nanoparticle uptake into cartilage-implications of the protein corona for novel arthritis treatments

U. von Mentzer et al.

Summary: This study evaluates the effects of protein coronas derived from osteoarthritis and rheumatoid arthritis patient synovial fluids, as well as fetal calf serum, on the uptake of nanoparticles into joint cartilage, chondrocytes, and monocytes. The results demonstrate that protein coronas significantly impact nanoparticle uptake in cartilage tissue and affect the uptake in chondrocytes and monocytes. This emphasizes the importance of considering the biological microenvironment for successful translation of drug delivery vehicles into clinics.

OSTEOARTHRITIS AND CARTILAGE (2022)

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Editorial Material Immunology

The cancer cell-derived extracellular vesicle glycocode in immunoevasion

Jenifer P. Goncalves et al.

Summary: Recent evidence suggests that cancer cell-derived extracellular vesicles may help cancer cells evade immune attack through changes in their glycocode. However, research on the glycocode of extracellular vesicles in cancer immunoevasion is still limited, but it holds promising potential for new diagnostic and therapeutic applications.

TRENDS IN IMMUNOLOGY (2022)

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Editorial Material Biochemistry & Molecular Biology

Patients as biomedical researchers

Delaney Liskey et al.

Summary: Advancements in biomedical research rely on critical thinking and problem solving, and the absence of patient representation hinders progress in health-related research.

TRENDS IN MOLECULAR MEDICINE (2022)

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Article Pharmacology & Pharmacy

Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy

Yang Xu et al.

Summary: This study fabricated microcrystals of an acid-sensitive stearoxyl-ketal-dexamethasone prodrug for local and sustained drug release in the treatment of arthritis. The prodrug demonstrated long-acting anti-arthritis effects with good safety, indicating the potential for developing new treatments for chronic diseases. Particle size and injection dose were found to influence the anti-inflammatory effect after intra-articular injection in a rat model of collagen-induced arthritis.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Materials Science, Biomaterials

Novel glucosamine-loaded thermosensitive hydrogels based on poloxamers for osteoarthritis therapy by intra-articular injection

Tingting Zhang et al.

Summary: This study successfully treated osteoarthritis in rabbits using thermosensitive hydrogels loaded with glucosamine, demonstrating good temperature sensitivity and therapeutic effect.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Pharmacology & Pharmacy

Nanotechnology application in drug delivery to osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OSP)

Morteza Rabiei et al.

Summary: Nanotechnology offers promising opportunities in orthopedics, including drug delivery, surface modification, regeneration, and diagnostics, with a focus on chronic orthopedic diseases. It has shown significant impact on diagnostics and treatments in recent years.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Engineering, Biomedical

The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

Zhi Peng et al.

Summary: Osteoarthritis (OA) is a leading cause of disability and socioeconomic loss globally, with current pharmacological treatments mainly palliative. Focus is shifting towards targeting cartilage extracellular matrix (ECM) destruction and abnormal homeostasis in OA for regenerative therapies, using potential biomarkers and preclinical studies to identify pathological stages.

BIOMATERIALS (2021)

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Article Biochemistry & Molecular Biology

Hyaluronan-Loaded Liposomal Dexamethasone-Diclofenac Nanoparticles for Local Osteoarthritis Treatment

Ming-Cheng Chang et al.

Summary: A novel OA treatment formulation HA-Lipo-DIC/DEX was developed to combat joint pain, showing safety and efficacy, indicating it could be a promising system for osteoarthritis pain control.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Biomaterials

Zein- vs PLGA-based nanoparticles containing rutin: A comparative investigation

Agnese Gagliardi et al.

Summary: This study compared the physico-chemical properties of nanosystems made from PLGA and zein, demonstrating that zein-based nanosystems had a greater ability to retain active compounds compared to PLGA particles. The study also showed that rutin-loaded zein nanoparticles exhibited significant in vitro antioxidant activity and were able to be intracellularly localized.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Review Biochemistry & Molecular Biology

A Review of the Use of Microparticles for Cartilage Tissue Engineering

Rachel J. Kulchar et al.

Summary: Tissue and organ failure present major concerns worldwide, leading to the emergence of tissue engineering as an alternative approach to organ transplantation. Advancements in microparticle technology have the potential to revolutionize cartilage tissue regeneration through drug delivery, controlled release systems, cell expansion, and scaffold formation. Further research is required to optimize clinical translation of these technologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Editorial Material Nanoscience & Nanotechnology

Extracellular vesicles versus synthetic nanoparticles for drug delivery

Kenneth W. Witwer et al.

Summary: Cell-released biological nanoparticles, known as extracellular vesicles (EVs), are emerging drug carriers with high complexity. EV-based drug delivery leverages intrinsic mechanisms for molecular transport in the body, and integrating EV biology and manufacturing with clinical insights from synthetic nanoparticles is likely to significantly advance the field of drug delivery.

NATURE REVIEWS MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Glycosaminoglycans in Tissue Engineering: A Review

Harkanwalpreet Sodhi et al.

Summary: Glycosaminoglycans play a crucial role in tissue engineering by driving stem cell fate and promoting cell proliferation, and recent studies have explored their use in tissue constructs. The research trends in this area are evaluated, providing insights into future directions.

BIOMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Doxorubicin Hydrochloride-Loaded Nonionic Surfactant Vesicles to Treat Metastatic and Non-Metastatic Breast Cancer

Martina Di Francesco et al.

Summary: This study developed nonionic surfactant vesicles (NSVs) loaded with doxorubicin hydrochloride (DOX) to improve therapeutic efficacy and reduce side effects. NSVs showed stable sustained drug release, better internalization and anticancer effect on breast cancer cells. The data suggested that DOX-loaded NSVs could be a promising nanocarrier for the potential treatment of metastatic breast cancer.

ACS OMEGA (2021)

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Article Biochemistry & Molecular Biology

Hyaluronate-functionalized hydroxyapatite nanoparticles laden with methotrexate and teriflunomide for the treatment of rheumatoid arthritis

Shweta Pandey et al.

Summary: HYA-HAMT-NP is a promising delivery system to avoid drug-induced hepatotoxicity in RA, showing better efficacy in treating RA.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee

Sunhee Jang et al.

Summary: Osteoarthritis (OA) is a degenerative and chronic joint disease that primarily damages joint cartilage, causing pain, swelling, and stiffness. With the aging population and increasing prevalence of obesity, the prevalence of OA is expected to rise. Recent advances in understanding the mechanisms, diagnosis, and management of OA have led to many potential therapeutic advances.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Biomarkers of Join Damage in Osteoarthritis: Current Status an Future Directions

Rajkamal Kumavat et al.

Summary: Osteoarthritis is a disease characterized by loss of cartilage and structural changes in bone, but there are currently no specific biomarkers available for diagnosis or treatment. The most urgent clinical need is for monitoring disease progression over a short period.

MEDIATORS OF INFLAMMATION (2021)

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Article Cell & Tissue Engineering

Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell

Jonathan Gobin et al.

Summary: This study investigated the production of extracellular vesicles (EVs) from human bone marrow-derived mesenchymal stromal cells using a bioreactor system. The EVs showed consistency in size, concentration, immunophenotype, and glycan profile. Additionally, the EVs exhibited immuno-regulatory constituents and could be generated in large quantities over a long production period with consistent quality.

STEM CELL RESEARCH & THERAPY (2021)

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Article Pharmacology & Pharmacy

Intra-Articular Slow-Release Triamcinolone Acetonide from Polyesteramide Microspheres as a Treatment for Osteoarthritis

Anna Tellegen et al.

Summary: This prospective study demonstrated the safety and proof-of-concept of IA-administered TA-PEAMs in treating OA pain and inflammation in dogs, showing potential for tissue regeneration.

PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis

Shi-Cong Tao et al.

Summary: OA is a common age-related degenerative joint disease with disturbance of ECM balance. CircRNA3503, increased after MT-induced cell sleep, acts as a sponge of hsa-miR-181c-3p and hsa-let-7b-3p to rescue IL-1 beta effects on OA. PLEL@circRNA3503-OE-sEVs show potential as an effective therapeutic strategy to prevent OA progression.

BIOACTIVE MATERIALS (2021)

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Review Engineering, Biomedical

Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges

Wenying Wei et al.

Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.

BIOACTIVE MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Influence of Materials Properties on Bio-Physical Features and Effectiveness of 3D-Scaffolds for Periodontal Regeneration

Nicola d'Avanzo et al.

Summary: Periodontal diseases are caused by infections and inflammation, leading to issues like bleeding gums and tooth loss. Approximately 10% of the global population suffers from severe periodontal diseases, highlighting the need for effective treatments. The use of 3D scaffolds can provide a platform for improving treatment efficacy and reducing systemic side effects.

MOLECULES (2021)

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Review Nutrition & Dietetics

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

Hongyun Lu et al.

Summary: Nanocarriers have attracted increasing attention due to their well-controlled release, enhanced distribution, and improved permeability for drug and food delivery strategies. Research has shown that drug and food delivery through nanocarriers, especially liposomes, has great potential and wide applications in pharmaceutical and food design. Safety concerns regarding nanocarriers have also been highlighted.

FRONTIERS IN NUTRITION (2021)

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Review Clinical Neurology

Management of Osteoarthritis: Expert Opinion on NSAIDs

Alberto Magni et al.

Summary: OA is a leading cause of disability among older adults worldwide, and the goal of treatment is to alleviate inflammatory pain and improve physical function. When selecting NSAIDs, factors such as patient age, comorbidities, polypharmacy, and benefit/risk balance need to be considered to reduce the risk of adverse events. The safety profiles of different NSAIDs are not straightforward, and a multidisciplinary approach is recommended to maximize therapy efficacy while minimizing untoward effects.

PAIN AND THERAPY (2021)

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Article Chemistry, Medicinal

A Simple and Quick Method for Loading Proteins in Extracellular Vesicles

Sara Busatto et al.

Summary: This study developed a quick, versatile, and simple method for loading proteins in extracellular vesicles (EVs) post-isolation. EVs showed similar levels of intracellular protein delivery as conventional methods, but with less toxicity. This method opens up opportunities for rapid exploration of EVs for protein delivery.

PHARMACEUTICALS (2021)

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Review Biology

The Biomechanics of Cartilage-An Overview

Joerg Eschweiler et al.

Summary: This article explores the structure and characteristics of articular cartilage, discussing various testing methods and modeling approaches, as well as factors influencing key properties of articular cartilage.

LIFE-BASEL (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Extracellular vesicle therapeutics from plasma and adipose tissue

Dalila Iannotta et al.

Summary: EVs are lipid-bilayer nanoparticles released by cells with therapeutic potential. Obtaining EVs from plasma and adipose tissue is a promising alternative to traditional cell culture methods.

NANO TODAY (2021)

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Review Nanoscience & Nanotechnology

Nanoparticle-Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Xu Li et al.

Summary: The review discusses the pathological features of osteoarthritis, the design concept for accurate drug localization within cartilage, interactions of nanoparticles with cartilage microenvironment, and advances in therapeutic schemes. The emphasis is on developing smart bioresponsive and multiple modality nanoparticles to interact with pathological signals.

NANO-MICRO LETTERS (2021)

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Article Genetics & Heredity

Synovium-Synovial Fluid Axis in Osteoarthritis Pathology: A Key Regulator of the Cartilage Degradation Process

Dhanashri Ingale et al.

Summary: Studying the levels of inflammatory mediators and MMPs in synovium and synovial fluid of different stages of OA can help in designing early-stage therapies or personalized disease management.

GENES (2021)

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Review Genetics & Heredity

Chondrodysplasias With Multiple Dislocations Caused by Defects in Glycosaminoglycan Synthesis

Johanne Dubail et al.

Summary: Chondrodysplasias with multiple dislocations are severe disorders characterized by joint laxity, multiple dislocations, severe short stature, hand anomalies, and/or vertebral anomalies. These disorders are mostly associated with mutations in genes encoding glycosyltransferases and sulfotransferases involved in the synthesis of glycosaminoglycans. Understanding the molecular mechanisms underlying these disorders is crucial for the development of biomarkers and therapeutics.

FRONTIERS IN GENETICS (2021)

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Article Biotechnology & Applied Microbiology

Tripterine and all-trans retinoic acid (ATRA) - loaded lipid-polymer hybrid nanoparticles for synergistic anti-arthritic therapy against inflammatory arthritis

Jichao Li et al.

Summary: The study developed Tripterine and all-trans retinoic acid loaded lipid-polymer hybrid nanoparticles for enhanced antiarthritic efficacy in arthritis conditions. The nanoparticles exhibited strong inhibitory effects on inflammatory markers and showed significant improvement in reducing inflammation compared to individual drugs. The co-delivery of drugs in nanoparticulate form could abolish the adverse effects of free drugs, indicating a promising therapeutic strategy for arthritis treatment.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2021)

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Article Engineering, Biomedical

EtoGel for Intra-Articular Drug Delivery: A New Challenge for Joint Diseases Treatment

Maria Chiara Cristiano et al.

Summary: Ethosomes(R) have shown potential as intra-articular drug delivery devices with longer residence time in the knee joint through modification of composition and preparation methods. Combining with a thermo-sensitive poloxamer gel could improve drug residence time in the joint, while also supporting joint movements at body temperature. These modified ethosomes showed no negative impact on human chondrocyte viability and exhibited suitable interactions with cells in in vitro studies.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2021)

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Article Engineering, Biomedical

Beyond Trial and Error: A Systematic Development of Liposomes Targeting Primary Macrophages

Florian Weber et al.

Summary: Monocytes/macrophages play a crucial role in tissue homeostasis, inflammation, and drug delivery, by selectively engulfing pathogens and drug carriers. A design of experiment strategy is proposed to optimize liposomal formulation for efficient macrophage targeting.

ADVANCED NANOBIOMED RESEARCH (2021)

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Article Pharmacology & Pharmacy

Nanoliposomes as Multidrug Carrier of Gemcitabine/Paclitaxel for the Effective Treatment of Metastatic Breast Cancer Disease: A Comparison with Gemzar and Taxol

Christian Celia et al.

Summary: Nanoliposomes co-delivering gemcitabine hydrochloride and paclitaxel significantly decrease cell viability, reduce tumor growth and improve survival times in metastatic breast cancer compared to combination treatment with the free drugs. Pharmacokinetic analysis shows that nanoliposomes increase the half-life of gemcitabine hydrochloride and paclitaxel, suggesting an effective treatment strategy for metastatic breast cancer.

ADVANCED THERAPEUTICS (2021)

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Review Cell Biology

The Role of Inflammation in the Pathogenesis of Osteoarthritis

Yoke Yue Chow et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Rheumatology

Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases

Rowan S. Hardy et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Review Rheumatology

Methotrexate and its mechanisms of action in inflammatory arthritis

Bruce N. Cronstein et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Article Chemistry, Multidisciplinary

Adipose-Derived Biogenic Nanoparticles for Suppression of Inflammation

Ming Tian et al.

SMALL (2020)

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Review Biotechnology & Applied Microbiology

Electrospun Polymers in Cartilage Engineering-State of Play

Elif Nur Yilmaz et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Rheumatology

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

Sharon L. Kolasinski et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Article Instruments & Instrumentation

The solid progress of nanomedicine

Joao Pedro Martins et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Review Immunology

Macrophage: A Potential Target on Cartilage Regeneration

Tiago Lazzaretti Fernandes et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound

Chung-Hwan Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Chemistry, Physical

The Effect of Synovial Fluid Composition, Speed and Load on Frictional Behaviour of Articular Cartilage

Denis Furmann et al.

MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

Yujie Liang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Orthopedics

Protein corona formation on particles in bovine synovial fluid and in a rat knee model of osteoarthritis

Y.Y. Shah et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

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Review Chemistry, Multidisciplinary

Bioprinting Tissue Analogues with Decellularized Extracellular Matrix Bioink for Regeneration and Tissue Models of Cartilage and Intervertebral Discs

Andrea J. Vernengo et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Surgery

Extracellular vesicles for treatment of solid organ ischemia-reperfusion injury

Mojahid Ali et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Review Nanoscience & Nanotechnology

Collagen: quantification, biomechanics and role of minor subtypes in cartilage

Benjamin J. Bielajew et al.

NATURE REVIEWS MATERIALS (2020)

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Article Cell Biology

The Role of Hyaluronic Acid in Cartilage Boundary Lubrication

Weifeng Lin et al.

CELLS (2020)

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Review Cell Biology

Hyaluronic Acid: Redefining Its Role

G. Abatangelo et al.

CELLS (2020)

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Article Biotechnology & Applied Microbiology

GEL-MAN Hydrogel Loaded With Triamcinolone Acetonide for the Treatment of Osteoarthritis

Kai Chen et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Thermoresponsive, hollow, degradable core -shell nanoparticles for intra- articular delivery of anti-inflammatory peptide

Marcus Deloney et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Cell & Tissue Engineering

A genomic biomarker that identifies human bone marrow-derived mesenchymal stem cells with high scalability

Padmapriya Sathiyanathan et al.

STEM CELLS (2020)

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Review Nutrition & Dietetics

Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials

Chun-De Liao et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

Carmen Corciulo et al.

SCIENTIFIC REPORTS (2020)

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Article Cell Biology

Glycan Node Analysis of Plasma-Derived Extracellular Vesicles

Sierra A. Walker et al.

CELLS (2020)

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Review Cell Biology

Molecular Signaling Interactions and Transport at the Osteochondral Interface: A Review

Mateus Oliveira Silva et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Chemistry, Physical

Polymer colloids as drug delivery systems for the treatment of arthritis

Tahani Saeedi et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

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Article Biotechnology & Applied Microbiology

Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein

Sara Busatto et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Engineering, Environmental

Microfluidic liposomes-anchored microgels as extended delivery platform for treatment of osteoarthritis

Jielai Yang et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Engineering, Biomedical

Palmitic acid-modified bovine serum albumin nanoparticles target scavenger receptor-A on activated macrophages to treat rheumatoid arthritis

Ting Gong et al.

BIOMATERIALS (2020)

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Review Cell & Tissue Engineering

Exosomes: roles and therapeutic potential in osteoarthritis

Zhenhong Ni et al.

BONE RESEARCH (2020)

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Article Materials Science, Biomaterials

Rapamycin-PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joints

Kaamini M. Dhanabalan et al.

BIOMATERIALS SCIENCE (2020)

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Article Materials Science, Biomaterials

Intra-articular injection of indomethacin-methotrexate in situ hydrogel for the synergistic treatment of rheumatoid arthritis

Na Yin et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Rheumatology

Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis

You-Jung Ha et al.

ARTHRITIS RESEARCH & THERAPY (2020)

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Article Materials Science, Biomaterials

Ultrasound-targeted microbubble destruction augmented synergistic therapy of rheumatoid arthritis via targeted liposomes

Liyun Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Materials Science, Biomaterials

Improving the anti-inflammatory efficacy of dexamethasone in the treatment of rheumatoid arthritis with polymerized stealth liposomes as a delivery vehicle

Qin Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Medicine, Research & Experimental

Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake

Shannon Brown et al.

MOLECULAR PHARMACEUTICS (2019)

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Review Orthopedics

Biophysical Stimuli: A Review of Electrical and Mechanical Stimulation in Hyaline Cartilage

Juan J. Vaca-Gonzalez et al.

CARTILAGE (2019)

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Review Pharmacology & Pharmacy

Triamcinolone Acetonide Extended-Release: A Review in Osteoarthritis Pain of the Knee

Julia Paik et al.

DRUGS (2019)

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Article Chemistry, Multidisciplinary

Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone

Florian A. Formica et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Chemistry, Multidisciplinary

Clinical cancer nanomedicine

Joy Wolfram et al.

NANO TODAY (2019)

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Article Nanoscience & Nanotechnology

Role of Liposome Size, Surface Charge, and PEGylation on Rheumatoid Arthritis Targeting Therapy

Hongwei Ren et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy

Lu Liu et al.

ACS NANO (2019)

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Article Medicine, Research & Experimental

Efficacy of Triamcinolone Acetonide Extended-Release in Participants with Unilateral Knee Osteoarthritis: A Post Hoc Analysis

Michael J. Langworthy et al.

ADVANCES IN THERAPY (2019)

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Article Engineering, Biomedical

Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles

Sara Busatto et al.

BIOMEDICAL MICRODEVICES (2019)

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Article Biotechnology & Applied Microbiology

Peptide-targeted liposomal delivery of dexamethasone for arthritis therapy

Rakeshchandra R. Meka et al.

NANOMEDICINE (2019)

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Article Polymer Science

Effect of steam sterilization and biocompatibility studies of hyaluronic acid hydrogel for viscosupplementation

Neena Haridas et al.

POLYMER DEGRADATION AND STABILITY (2019)

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Review Pharmacology & Pharmacy

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Ana Claudia Lima et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Biochemistry & Molecular Biology

pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization

Luise L. Chaves et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Review Genetics & Heredity

Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis

Marina Nemtsova et al.

FRONTIERS IN GENETICS (2019)

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Review Cell Biology

Adipose-derived cellular and cell-derived regenerative therapies in dermatology and aesthetic rejuvenation

Annie Suh et al.

AGEING RESEARCH REVIEWS (2019)

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Editorial Material Pharmacology & Pharmacy

Do niosomes have a place in the field of drug delivery?

Rita Muzzalupo et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

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Article Chemistry, Multidisciplinary

Triamcinolone acetonide-loaded PLA/PEG-PDL microparticles for effective intra-articular delivery: synthesis, optimization, in vitro and in vivo evaluation

May Abou-ElNour et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Multidisciplinary Sciences

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Stephan Culemann et al.

NATURE (2019)

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Review Pharmacology & Pharmacy

Systemic drugs with impact on osteoarthritis

Dragos Apostu et al.

DRUG METABOLISM REVIEWS (2019)

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Article Pharmacology & Pharmacy

Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications

Shuo Chen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

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Article Chemistry, Physical

Biolubrication synergy: Hyaluronan - Phospholipid interactions at interfaces

Andra Dedinaite et al.

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Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways

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Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix

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Characterization and application of size-sorted zonal chondrocytes for articular cartilage regeneration

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Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: An overview

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Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model

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Intra-articular knee implantation of autologous bone marrow-derived mesenchymal stromal cells in rheumatoid arthritis patients with knee involvement: Results of a randomized, triple-blind, placebo-controlled phase 1/2 clinical trial

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Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study

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Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints

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Extracellular vesicle therapeutics for liver disease

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Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)

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Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With Rheumatoid Arthritis A Randomized Clinical Trial

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Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis

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Diagnosis and management of rheumatoid arthritis in adults: summary of updated NICE guidance

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Nano based drug delivery systems: recent developments and future prospects

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis

Norio Goto et al.

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Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis

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Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model

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Intra-articular Retention and Anti-arthritic Effects in Collagen-Induced Arthritis Model Mice by Injectable Small Interfering RNA Containing Hydrogel

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Thermo-sensitive injectable hydrogel based on the physical mixing of hyaluronic acid and Pluronic F-127 for sustained NSAID delivery

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Mesenchymal stem cell therapy for knee osteoarthritis: 5years follow-up of three patients

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Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection

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Macrophage heterogeneity in the context of rheumatoid arthritis

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Enzyme-responsive multistage vector for drug delivery to tumor tissue

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A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis

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Extracellular Vesicles as Drug Delivery Vehicles for Rheumatoid Arthritis

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Hesperetin Liposomes for Cancer Therapy

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Intra-Articular Injection of Cross-Linked Hyaluronic Acid-Dexamethasone Hydrogel Attenuates Osteoarthritis: An Experimental Study in a Rat Model of Osteoarthritis

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Multistage vector delivery of sulindac and silymarin for prevention of colon cancer

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Safety of Nanoparticles in Medicine

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Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

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A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapy

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Joint Surface-Active Phospholipid-Mimetic Liposomes for Intra-Articular Delivery of Paclitaxel

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An Intra-Articular, Extended-Release Formulation of Triamcinolone Acetonide Prolongs and Amplifies Analgesic Effect in Patients with Osteoarthritis of the Knee

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[18]F FDG PET/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis

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Sustained efficacy of a single intra-articular dose of FX006 in a rat model of repeated localized knee arthritis

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Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration

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Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model

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Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction

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Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis

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Unique biomaterial compositions direct bone marrow stem cells into specific chondrocytic phenotypes corresponding to the various zones of articular cartilage

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Evaluation of intra-articular delivery of hyaluronic acid functionalized biopolymeric nanoparticles in healthy rat knees

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Addressing the problem of cationic lipid-mediated toxicity: The magnetoliposome model

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Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

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Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis - Involvement of matrix metalloproteinase 3

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Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate

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BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2005)

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Scintigraphic imaging of radiolabelled drug delivery systems in rabbits with arthritis

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Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention

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Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint

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Efficacy of chitosen microspheres for controlled intra-articular of celecoxib in inflamed joins

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Biodegradable ibuprofen-loaded PLGA microspheres for intraarticular administration -: Effect of Labrafil addition on release in vitro

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Hyaluronic acid hydrogel in the treatment of osteoarthritis

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Transforming growth factor-β in calcium alginate beads for the treatment of articular cartilage defects in the rabbit

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Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

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Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications - Results of a two-year, randomized, double-blind, placebo-controlled trial

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Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit

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Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium

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Renal failure associated with the use of celecoxib and rofecoxib

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A comparison of renal-related adverse drug reactions between rofecoxib and celecoxib, based on the World Health Organization Uppsala Monitoring Centre safety database

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Diffusion of paramagnetically labeled proteins in cartilage: Enhancement of the 1-D NMR imaging technique

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Sustained-release dexamethasone palmitate - Pharmacokinetics and efficacy in patients with activated inflammatory osteoarthritis of the knee

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Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis - The CLASS study: A randomized controlled trial

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Oral versus topical NSAIDs in rheumatic diseases - A comparison

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