Journal
ACS NANO
Volume 16, Issue 12, Pages 20805-20819Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c08047
Keywords
photodynamic therapy; radiotherapy; cerium oxide; hypoxia; computed tomography
Categories
Funding
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province
- Natural Science Foundation of Shandong Province
- China Postdoctoral Science Foundation
- Student Research and Innovation Fund of the Fundamental Research Funds for the Central Universities
- [51972075]
- [51972076]
- [52002091]
- [22205048]
- [U22A20347]
- [YQ2022B003]
- [ZR2019ZD29]
- [2022M710931]
- [3072020GIP1016]
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The versatile core-shell radiosensitizer (SSCP) was designed to enhance X-ray-induced photodynamic therapy (X-PDT) by perfectly absorbing ultraviolet light and generating reactive oxygen species (ROS). The addition of cerium oxide further improves the efficiency of radiotherapy. SSCP also shows great potential in preclinical imaging and clinical translation.
The emergence of X-ray-induced photodynamic therapy (X-PDT) holds tremendous promise for clinical deep-penetrating cancer therapy. However, the clinical application of X-PDT in cancer treatment is still limited due to the hypoxic property of cancerous tissue, the inherent antioxidant system of tumor cells, and the difficulty in matching the absorption spectra of photosensitizers. Herein, a versatile core-shell radiosensitizer (SCNPs@DMSN@CeOx-PEG, denoted as SSCP) was elaborately designed and constructed to enhance X-PDT by coating tunable mesoporous silica on nanoscintillators, followed by embedding the cerium oxide nanoparticles in situ. The obtained SSCP radiosensitizer demonstrated a distinct blue-shift in the ultra-violet light region, so that it could perfectly absorb the ultraviolet light converted by the SCNPs core, resulting in the formation of photoinduced electron-hole (e--h+) pairs separation to generate reactive oxygen species (ROS). In addition, the cerium oxide exhibits high glutathione consumption to heighten ROS accumulation, and catalase-like activity to alleviate the hypoxia, which further enhances the efficiency of radiotherapy. Benefiting from the abundant Lu and Ce elements, the computed tomography imaging performance of SSCP is about 3.79-fold that of the clinical contrast agent (iohexol), which has great potential in both preclinical imaging and clinical translation.
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