4.8 Article

Analyses of Pore-Size-Dependent Ionic Transport in Nanopores in the Presence of Concentration and Temperature Gradients

Journal

ACS APPLIED MATERIALS & INTERFACES
Volume 15, Issue 1, Pages 2409-2418

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c17925

Keywords

nanopores; diffusioosmosis; human signaling; ionic transport; cryo-anesthesia

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We report a nanopore-integrated microfluidic platform to characterize ion transport in the presence of electrolyte and temperature gradients. Various nanopores with different pore sizes were produced using our previous self-assembled particle membrane (SAPM)-integrated microfluidic platform. Pore-size-dependent ionic transport was quantified by measuring the short circuit current (SCC) and open circuit voltage (OCV) across different nanopores by manipulating the electrolyte and temperature gradients. Three simple theoretical models heavily depending on pore size, electrolyte concentration, and temperature were established and validated with experimental results. The results of this study would help clarify ion transport phenomena at low-temperature conditions and enable practical applications of cryo-anesthesia in the near future.
Mass transport through nanopores occurs in various natural systems, including the human body. For example, ion transport across nerve cell membranes plays a significant role in neural signal transmission, which can be significantly affected by the electrolyte and temperature conditions. To better understand and control the underlying nanoscopic transport, it is necessary to develop multiphysical transport models as well as validate them using enhanced experimental methods for facile nanopore fabrication and precise nanoscale transport characterization. Here, we report a nanopore-integrated microfluidic platform to characterize ion transport in the presence of electrolyte and temperature gradients; we employ our previous self-assembled particle membrane (SAPM)-integrated microfluidic platform to produce various nanopores with different pore sizes. Subsequently, we quantify pore-size-dependent ionic transport by measuring the short circuit current (SCC) and open circuit voltage (OCV) across various nanopores by manipulating the electrolyte and temperature gradients. We establish three simple theoretical models that heavily depend on pore size, electrolyte concentration, and temperature and subsequently validate them with the experimental results. Finally, we anticipate that the results of this study would help clarify ion transport phenomena at low-temperature conditions, not only providing a fundamental understanding but also enabling practical applications of cryo-anesthesia in the near future.

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