Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 50, Pages 55342-55353Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c15820
Keywords
injectable hydrogels; self-healing hydrogel; zwitterionic hydrogel; anti-bacterial adhesion; wound dressing
Funding
- National Natural Science Foundation of China [81171731]
- China Postdoctoral Science Foundation [2021M702349]
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYJC21077, ZYJC21026]
- Science and Technology Major Project of Tibetan Autonomous Region of China [XZ202201ZD0001G]
- Fundamental Research Funds for the Central Universities [2022SCU12062]
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In this study, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed. The hydrogel showed a distinct thermal-induced sol-gel transition and could be easily applied to complex wounds. It possessed rapid self-healing ability and low cytotoxicity, and effectively prevented bacterial adhesion, promoting wound healing.
It is highly desired yet challenging to fabricate biocompatible injectable self-healing hydrogels with anti-bacterial adhesion properties for complex wounds that can autonomously adapt to different shapes and depths and can promote angiogenesis and dermal collagen synthesis for rapid wound healing. Herein, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed from a thermoresponsive ABA triblock copolymer poly[(N-isopropyl acrylamide)-co-(butyl acrylate)-co-(sulfobetaine meth-acrylate)]-b-poly(ethylene glycol)-b-poly[(N-isopropyl acrylamide)-co- (butyl acrylate)-co-(sulfobetaine methacrylate)] (PZOPZ). The prepared PZOPZ hydrogel exhibits a distinct thermal-induced sol-gel transition around physiological temperature and could be easily applied in a sol state and in situ gelled to adapt complex wounds of different shapes and depths for complete coverage. Meanwhile, the hydrogel possesses a rapid self -healing ability and can recover autonomously from damage to maintain structural and functional integrity. In addition, the CCK-8 and 2D/3D cell culture experiments revealed that the PZOPZ hydrogel dressing shows low cytotoxicity to L929 cells and can effectively prevent the adhesion of Staphylococcus aureus and Escherichia coli. In vivo investigations verified that the PZOPZ hydrogel could increase angiogenesis and dermal collagen synthesis and shorten the transition from the inflammatory to the proliferative stage, thereby providing more favorable conditions for faster wound healing. Overall, this work provides a promising strategy to develop injectable zwitterionic hydrogel dressings with multiple functions for clinic wound management.
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