4.8 Article

Iridium Tungstate Nanozyme-Mediated Hypoxic Regulation and Anti-inflammation for Duplex Imaging Guided Photothermal Therapy of Metastatic Breast Tumors

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Rheumatoid arthritis microenvironment insights into treatment effect of nanomaterials

Yan Zhu et al.

Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.

NANO TODAY (2022)

Article Oncology

Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019

Jonathan M. Kocarnik et al.

Summary: The global burden of cancer is substantial and growing, with differences in burden based on Sociodemographic Index (SDI). The largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles from 2010 to 2019.

JAMA ONCOLOGY (2022)

Article Chemistry, Multidisciplinary

Biodegradable MnO-Based Nanoparticles with Engineering Surface for Tumor Therapy: Simultaneous Fenton-Like Ion Delivery and Immune Activation

Zhaoli Sun et al.

Summary: Manganese nanoparticles designed for immune activation and tumor therapy show promising potential for tumor theranostics.

ACS NANO (2022)

Article Engineering, Environmental

Ultrasmall platinum nanozymes as broad-spectrum antioxidants for theranostic application in acute kidney injury

Dong-Yang Zhang et al.

Summary: The study developed ultrasmall polyvinylpyrmlidone-coated platinum nanoparticles as multienzyme mimetics and demonstrated their effectiveness in relieving clinical symptoms of AKI in mice. These nanoparticles showed relatively low toxicity and side effects in vivo and rapid excretion from healthy mice. The research highlights the potential of these Pt nanozymes as a novel antioxidant for AKI treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Chemistry, Multidisciplinary

A Nanozyme-Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke

Juqun Xi et al.

Summary: This study presents a novel strategy to design an artificial peroxisome using a nanozyme with stable and multiple enzymatic activities, which shows promising therapeutic effects for treating hyperuricemia and protecting neurons during ischemic stroke. The nanozyme-based artificial peroxisome is considered a promising candidate for in vivo functions.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Regulating Tumor N6-Methyladenosine Methylation Landscape using Hypoxia-Modulating OsSx Nanoparticles

Yue Zheng et al.

Summary: A new type of nanocatalyst nanoparticles has been developed to downregulate genes involved in hypoxia pathway, elevate RNA m(6)A methylation levels, and degrade mRNA of hypoxia-related genes, thereby improving tumor hypoxia. This research sheds light on the potential of regulating RNA modification to overcome chemoresistance, providing a new avenue for understanding the underlying mechanisms of hypoxia-modulating nanomaterials.

SMALL (2021)

Article Chemistry, Multidisciplinary

Platinum-Doped Prussian Blue Nanozymes for Multiwavelength Bioimaging Guided Photothermal Therapy of Tumor and Anti-Inflammation

Zi-Hao Li et al.

Summary: This study developed platinum-doped Prussian blue (PtPB) nanozymes with tunable spectral absorption, high photothermal conversion efficiency, and antioxidative catalytic activity, providing a new paradigm for designing safe and efficient photothermal agents for complex tumor diseases. The PtPB nanozymes exhibited tunable LSPR frequency, significantly enhanced photothermal conversion efficiency, and good biosafety after intravenous injection. The experimental and theoretical results revealed the mechanisms behind the enhanced photothermal conversion efficiency of PtPB with tunable LSPR frequency.

ACS NANO (2021)

Article Materials Science, Multidisciplinary

Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury

Xu Chen et al.

Summary: The study developed a novel mesoporous selenium-hyaluronic acid nanoenzyme therapeutic system to target and eliminate ROS in inflammatory immune cells for treating local inflammation and sepsis injury, showing high activity, broad spectrum ROS elimination capacity, and enhanced targeting properties. In vivo experiments demonstrated significant improvements in survival rate and organ function in sepsis mouse models after treatment with this nanozyme system.

APPLIED MATERIALS TODAY (2021)

Article Chemistry, Multidisciplinary

Near-Infrared II Light-Triggered Robust Carbon Radical Generation for Combined Photothermal and Thermodynamic Therapy of Hypoxic Tumors

Xin Liu et al.

Summary: This study introduces an azo-containing polymer for combined photothermal and thermodynamic therapy in the NIR II biowindow, which can induce cancer cell death even under a hypoxic tumor microenvironment. RNA-sequencing is used to reveal the impact of the combined therapy on the cell transcriptome.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Engineering, Biomedical

Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/ nitrogen species scavengers for acute kidney injury management

Dong-Yang Zhang et al.

Summary: This study introduced ultrasmall polyvinylpyrrolidone-coated iridium nanoparticles as a promising new artificial enzyme to scavenge RONS and protect against AKI. The nanoparticles showed preferential renal uptake and alleviated clinical symptoms in mice, with relatively low systemic side effects due to rapid renal clearance. The research demonstrates the clinically translatable potential of ultrasmall nanozymes for AKI management.

BIOMATERIALS (2021)

Article Multidisciplinary Sciences

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Wei Feng et al.

Summary: Materials with enzymatic-like activities, such as 2D vanadium carbide MXene nanozymes, show promise in treating inflammatory and neurodegenerative diseases mediated by reactive oxygen species.

NATURE COMMUNICATIONS (2021)

Article Engineering, Biomedical

Mutual-reinforcing sonodynamic therapy against Rheumatoid Arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme

Wen Li et al.

Summary: The strategy developed provides effective sonodynamic therapy under hypoxic microenvironment for the treatment of rheumatoid arthritis (RA), with promising prospects for highly efficient treatment.

BIOMATERIALS (2021)

Article Biotechnology & Applied Microbiology

Prussian blue-based theranostics for ameliorating acute kidney injury

Dong-Yang Zhang et al.

Summary: In this study, ultrasmall Prussian blue nanozymes were synthesized as theranostics for AKI treatment, showing excellent performance in eliminating RONS and treating AKI, suggesting great potential for AKI management.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Biochemistry & Molecular Biology

Inflammation and tumor progression: signaling pathways and targeted intervention

Huakan Zhao et al.

Summary: Inflammation plays a crucial role in cancer development and therapy, either promoting or inhibiting tumor progression and therapeutic outcomes. Various signaling pathways and factors have been identified as pivotal regulators of inflammation initiation and resolution.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Multidisciplinary Sciences

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

Max D. Wellenstein et al.

NATURE (2019)

Article Nanoscience & Nanotechnology

Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

Xuefei Lu et al.

NATURE NANOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Ines Godet et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Article Chemistry, Multidisciplinary

A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows

Han Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Review Oncology

Inflammation fires up cancer metastasis

Bin-Zhi Qian

SEMINARS IN CANCER BIOLOGY (2017)

Article Nanoscience & Nanotechnology

Dual Functions of Cyclometalated Iridium(III) Complexes: Anti-Metastasis and Lysosome-Damaged Photodynamic Therapy

Fang-Xin Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Article Chemistry, Multidisciplinary

A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

Namrata Singh et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

Angiogenesis and Inflammation Crosstalk in Diabetic Retinopathy

Margarida Capitao et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Elucidating the Fundamental Mechanisms of Cell Death Triggered by Photothermal Therapy

Jilian R. Melamed et al.

ACS NANO (2015)

Review Pharmacology & Pharmacy

Cancer metastases: challenges and opportunities

Xiangming Guan

ACTA PHARMACEUTICA SINICA B (2015)

Article Multidisciplinary Sciences

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Ting Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

Bradley N. Bidwell et al.

NATURE MEDICINE (2012)

Review Multidisciplinary Sciences

A Perspective on Cancer Cell Metastasis

Christine L. Chaffer et al.

SCIENCE (2011)

Review Oncology

Hypoxia, inflammation, and the tumor microenvironment in metastatic disease

Elizabeth C. Finger et al.

CANCER AND METASTASIS REVIEWS (2010)

Review Biochemistry & Molecular Biology

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov et al.

Review Oncology

Hypoxia-driven selection of the metastatic phenotype

Richard Sullivan et al.

CANCER AND METASTASIS REVIEWS (2007)

Article Multidisciplinary Sciences

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

DC Radisky et al.

NATURE (2005)

Review Immunology

Oxygen free radicals and systemic autoimmunity

H Ahsan et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2003)