4.5 Article

Chronic pregabalin treatment decreases excitability of dentate gyrus and accelerates maturation of adult-born granule cells

Journal

JOURNAL OF NEUROCHEMISTRY
Volume 140, Issue 2, Pages 257-267

Publisher

WILEY-BLACKWELL
DOI: 10.1111/jnc.13740

Keywords

dentate gyrus; Gabapentin; neurogenesis; Pregabalin

Funding

  1. National Agency for Promotion of Science and Technology (ANPCyT) [BID PICT 2013-2202, BID PICT 20112667, BID PICT 2012-1931]
  2. University of Buenos Aires [UBACyT 20020130100666BA]
  3. CONICET [PIP-11220110100768]

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Pregabalin (PGB) is extensively prescribed to treat neurological and neuropsychiatrical conditions such as neuropathic pain, anxiety disorders, and epilepsy. Although PGB is known to bind selectively to the alpha 2d subunit of voltage-gated calcium channels, there is little understanding about how it exerts its therapeutic effects. In this article, we analyzed the effects of an in vivo chronic treatment with PGB over the physiology of dentate gyrus granule cells (DGGCs) using ex vivo electrophysiological and morphological analysis in adult mice. We found that PGB decreases neuronal excitability of DGGCs. In addition, PGB accelerates maturation of adult-born DGGCs, an effect that would modify dentate gyrus plasticity. Together, these findings suggest that PGB reduces activity in the dentate gyrus and modulates overall network plasticity, which might contribute to its therapeutic effects.

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