Association between serum uric acid and relative hand grip strength in comparison with metabolic syndrome components

Objectives: To investigate the association between serum uric acid (UA) and relative hand grip strength (HGS) in comparison with metabolic syndrome components. Methods: We analyzed the data of 5247 Korean adults aged >= 20 years (2422 men and 2825 women) who participated in the KNHNES VII (2018). Results: Among women, relative HGS was significantly lower in participants with hyperuricemia (1.65 +/- 0.04) than in those without (1.95 +/- 0.01) and was significantly decreased in the highest quartile (4Q: 1.77 +/- 0.02) of serum UA compared with that in the lowest quartile (1Q: 1.98 +/- 0.02). Among men, relative HGS was lower in participants with hyperuricemia (3.09 +/- 0.04 vs. 3.16 +/- 0.02) and decreased in 4Q (3.08 +/- 0.03) of serum UA compared with that in 1Q (3.15 +/- 0.03); however, these results were not statistically significant. In age- and multivariate-adjusted analyses in men, relative HGS was significantly lower in 4Q compared with that in 1Q in model 1 (adjusted for age), but there were no significant differences in model 2 (adjusted for age, BMI, and waist circumference) and model 3 ( adjusted for age, BMI, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, triglycerides, and high-density lipoprotein cholesterol). Meanwhile, in women, relative HGS was significantly decreased in 4Q compared with that in 1Q in all models. Conclusions: A significant inverse correlation was observed between serum UA levels and relative HGS in women, and their significance was maintained even after adjusting for age and metabolic syndrome components. (c) 2022 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

The study found a significant inverse correlation between serum uric acid levels and relative hand grip strength in women, indicating that higher uric acid levels are associated with lower grip strength. This association remained even after adjusting for age and metabolic syndrome components.