Journal
ADVANCED MATERIALS
Volume 27, Issue 41, Pages 6450-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502865
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Funding
- National Basic Research Program of China (973 Program) [2012CB933600]
- National Natural Science Foundation of China [30970723, 51173150, 51373138, 21574105]
- Construction Program for Innovative Research Team of University in Sichuan Province [14TD0050]
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A size changeable polymer micelle system with a dual shell, which increases in size under acidic pH conditions and is altered to smaller micelles, triggered by intracellular glutathione (GSH), is successfully developed. It is capable of direct delivering anticancer drugs to the nucleus of multidrug resistance (MDR) tumor cells for highly effective combating of drug resistant breast cancer.
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