Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 4, Pages 1203-1207Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b01130
Keywords
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Funding
- National Natural Science Foundation of China [21372228]
- Yunnan Applied Basic Research Projects [2014FB166]
- Youth Innovation Promotion Association of CAS [2015323]
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Myritonines A-C (1-3), three new alkaloids bearing an unprecedented heterohexacyclic skeleton, were isolated from Myrioneuron tonkinensis. Their structures were determined by a combination of spectroscopic data and single crystal X-ray diffraction analysis. Compound 3 represents the first Myrioneuron alkaloid featuring a unique trans-decahydroquinoline motif and was also found to possess a rare cyano functionality. Compounds 1 and 2 showed inhibition against the hepatitis C virus in vitro.
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