Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 10, Pages 2674-2680Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00625
Keywords
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Funding
- Ministry of Science and Technology of Taiwan [NSC 102-2628-B-037-003-MY3, MOST 103-2320-B-037-005-MY2, MOST103-2628-B-037-001-MY3, MOST 105-2911-I-002-302, 103-2911-I-002-303, 103-2325-B-039-008, 103-2325-B-039-007-CC1, 102-2320-B-037-012-MY2]
- Kaohsiung Medical University [KMU-TP104E39, KMU-TP104A26]
- Ministry of Health and Welfare of Taiwan [MOHW105-TDU-B-212-134007]
- Health and Welfare Surcharge of Tobacco Products
- National Health Research Institutes [NHRI-EX103-10241BI]
- Chinese Medicine Research Center, China Medical University (Ministry of Education, Aim for the Top University Plan)
- Joint Center for High Valued Instrument, National Sun Yat-sen University
- Center for Research Resources and Development, Kaohsiung Medical University
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Zoanthus kuroshio is a colorful zoanthid with a fluorescent pink oral disc and brown tentacles, which dominates certain parts of the Taiwanese and Japanese coasts. This sea anemone is a rich source of biologically active alkaloids. In the current investigation, two novel halogenated zoanthamines [5 alpha-iodozoanthenamine (1) and 11 beta-chloro-11-deoxykuroshine A (2)], along with four new zoanthamines [18-epi-kuroshine A (3), 7 alpha-hydroxykuroshine E (4), 5 alpha-methoxykuroshine E (5), and 18-epi-kuroshine E (6)], and six known compounds were isolated from Z. kuroshio. Compounds 1 and 2 are the first examples of halogenated zoanthamine-type alkaloids isolated from nature. Compounds 3 and 6 are the first zoanthamine stereoisomers with a cis-junction of the A/B rings. All isolated compounds were evaluated for their anti-inflammatory activities by measuring their effects on superoxide anion generation and elastase release by human neutrophils in response to fMLP.
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