Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 6, Pages 1702-1706Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00286
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Funding
- BBSRC [BB/M022579/1] Funding Source: UKRI
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Bacterial infections resulting from nonsurgical traumatic wounds can be life threatening, especially those caused by multidrug-resistant (MDR) bacteria with limited therapeutic options. The antimicrobial activity of polymyxin B (1) and curcumin (2) alone and in combination was determined versus MDR bacterial isolates associated with traumatic wound infections. Cytotoxicity assays for 1 and 2 were undertaken in keratinocyte cell lines. Minimum inhibitory concentrations of 1 were significantly reduced in the presence of 2 (3- to 10-fold reduction), with synergy observed. Time-kill assays showed the combinations produced bactericidal activity. Cytotoxicity assays indicate the toxicity of 2 was reduced in the presence of 1.
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