Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 12, Pages 3134-3142Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00910
Keywords
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Funding
- Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]
- National Natural Science Foundation of China [31370372, 81573316, 81641129]
- National Science and Technology Project of China [2011ZX09102-004]
- Fundamental Research Fund for the Central Universities [2016YXMS149]
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Eighteen compounds, including eight new cassane-type furanoditerpenoids, 3 beta-hydroxyphanginin H (1), 3 beta-acetoxyphanginin H (2), 7 beta-acetoxyphanginin H (3), 7,beta-hydroxyphanginin 1-1 (4), 4-epi-3,6-hydroxycaesalpinilinn (5), 4-epi-3 beta-acetoxycaesalpinilinn (6), 20-acetoxytaepeenin D (7), and tomocin E (8), along with 10 known compounds (9-18) were isolated from the roots of Caesalpinia decapetala. Compounds 1-13 were isolated from C. decapetala for the first time. The new compounds with their absolute configurations were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 1, 4, 5, 7, and 11 exhibited inhibitory activities against the SW1990 human pancreatic cancer cell line with IC50 values ranging from 2.9 to 8.9 mu M.
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