Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 12, Pages 3065-3071Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00720
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Funding
- Kanae Foundation for the Promotion of Medical Science
- JSPS Kakenhi [JP26860068]
- grant for Research Support Year at the National University of Mongolia
- Kanno Foundation of Japan
- Grants-in-Aid for Scientific Research [26860068] Funding Source: KAKEN
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Chemical investigation of the aerial parts of Atraphaxis frutescens resulted in the isolation of five 7-methoxyflavonols with pyrogallol B-ring moieties (1-5), a fisetinidol glucoside (13), and a benzyl glycoside (18), together with 26 known compounds including flavonoids, phenylpropanoid amides, anthraquinone glycosides, lignans, and a benzyl derivative. The principal chemical structural feature of the isolated compounds was either a pyrogallol or catechol B-ring moiety, and they showed potent 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities.. To assess the effects of these antioxidants on biological enzymes, their inhibitory effects against an insect phenoloxidase and a mushroom tyrosinase were evaluated. This study indicated that insect phenoloxidase was inhibited by phenylpropanoid amides and that mushroom tyrosinase was inhibited by the characteristic 7-methoxyflavonol 3-O-rhamnopyranosides.
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