Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 5, Pages 1454-1458Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00177
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Funding
- Fundacao de Amparo a Pesquisa do Estado do Mato Grosso (FAPEMAT)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- INFAR/UNIFESP Confocal and Flow Cytometry Facility
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Conselho Nacional de Pesquisa Cientifica (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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A new orbitide named [1-8-N alpha C]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).
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