Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 4, Pages 1035-1047Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b01103
Keywords
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Funding
- 973 Program [2015CB755906]
- NSFC-Shangdong Join Fund for Marine Science [U1406402]
- National Hi-Tech 863-Projects [2011AA090701, 2013AA092902]
- COMRA [DY125-15-T-01]
- Sino-German Project [GZ816]
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Chemical examination of an EtOAc extract of a cultured Acremonium sp. fungus from deep-sea sediments resulted in the isolation of 15 new eremophilane-type sesquiterpenoids, namely, acremeremophilanes A-O (1-15), together with seven known analogues. The structures of new compounds were determined through extensive spectroscopic analyses, in association with chemical conversions and ECD calculations for configurational assignments. The PIKS-derived 4-hexenoic acid unit in 2-6 is rarely found in nature. All compounds were evaluated for inhibitory effects toward nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophage cells. Compounds 2-6 and 14 exhibited inhibitory effects with IC50 values ranging from 8 to 45 mu M.
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