Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 4, Pages 767-774Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00691
Keywords
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Funding
- Natural Product Research Center of Excellence, Prince of Songkla University
- Faculty of Science Research Fund
- Graduate School, Prince of Songkla University
- Swiss government, through the Federal Commission for Scholarships for Foreign Students (FCS)
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Seven new compounds constituted by three secoiridoids (1-3), two isocoumarins (4 and 5), an iridoid (6), and an aromatic derivative (7) in addition to 24 known compounds were isolated from the stem bark of Fagraea fragrans. The structures of the new compounds were determined on the basis of spectroscopic data analysis. The isolated compounds showed no antibacterial activity against Staphylococcus aureus and Escherichia coli. However, 5-formylisochromen-1-one (4), (-)-mellein (8), and swermacrolactone C (9) exhibited potent antimycobacterial activities against Mycobacterium smegmatis when used in combination with the antibiotic drug erythromycin.
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