Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 9, Pages 2376-2383Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00566
Keywords
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Science, ICT, and Future Planning [NRF-2013R1A2A2A01016296]
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Eight new compounds (1-8), including five acylphloroglucinolated catechins (1-5) and three phenylethyl isocoumarin glycosides (6-8), were isolated from Agrimonia pilosa along with six other known compounds (9-14). The new compounds were characterized structurally by NMR, MS, and ECD analyses. Compounds 4 and 5 were assigned as acylphloroglucinolated procyanidin derivatives, which are described for the first time from Nature. The absolute configuration of compound 8 was elucidated by computational analysis of its ECD spectrum. The isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced NO production in BV2 microglial cells.
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