Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 10, Pages 2635-2643Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00554
Keywords
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Funding
- National Natural Science Foundation of China [81273493]
- Natural Science Foundation of Fujian Province of China [2016J01367]
- Fujian Medical University [09ZD009]
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To examine the effect of koumine, a Gelsemium a kaloid, on two experimental models of rheumatoid arthritis (RA), rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) were administered koumine (0.6, 3, or 15 mg/kg/day) or vehicle thiough gastric gavage (i.g.). Clinical evaluation was performed via measurements of hind paw volume, arthritis index (AI) score, mechanical withdrawal threshold, organ weight, and by radiographic and histological examinations. Levels of interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and antitype II collagen (CII) antibody were also examined. In rats with AIA, koumine reduced the AI score and mechanical allodynia of the injected hind paw in a dose-dependent manner and significantly inhibited increase in thymus and liver weights. In rats with CIA, koumine inhibited increase in hind paw volume, AI score, and mechanical allodynia in a dose-dependent manner and reduced joint space narrowing. Furthermore, koumine also attenuated the increase in the expression of IL-1 beta and TNF-alpha, as well as the robust increase of serum anti-CII antibodies in response to immunization. These results suggested that koumine effectively attenuated arthritis progression in two rat models of RA and that this therapeutic effect may be associated with its immunoregulatory action.
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