Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 6, Pages 1554-1566Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b01115
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Funding
- Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
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Methyl gallate (MG) is a prevalent phenolic acid in the plant kingdom, and its presence in herbal medicines might be related to its remarkable biological effects, such as its antioxidant, antitumor, and antimicrobial activities. Although some indirect evidence suggests anti-inflammatory activity for MG, there are no studies demonstrating this effect in animal models. Herein, we demonstrated that MG (0.7-70 mg/kg) inhibited zymosan-induced experimental arthritis in a dose dependent manner. The oral administration of MG (7 mg/kg) attenuates arthritis induced by z-ymosan, affecting edema formation, leukocyte migration, and the production of inflammatory mediators (IL-1 beta, IL-6, TNF-alpha, CXCL-1, LTB4, and PGE(2)). Pretreatment with MG inhibited in vitro neutrophil chemotaxis elicited by CXCL-1, as well as the adhesion of these cells to TNF-alpha-primed endothelial cells. MG also impaired zymosan-stimulated macrophages by inhibiting IL-6 and NO production, COX-2 and iNOS expression, and intracellular calcium mobilization. Thus, MG is likely to present an anti-inflammatory effect by targeting multiple cellular events such as the production of various inflammatory mediators, as well as leukocyte activation and migration.
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