Journal
JOURNAL OF NATURAL PRODUCTS
Volume 79, Issue 3, Pages 564-569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00968
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Funding
- University of Otago
- Dodd-Walls Centre
- ARS [ARS-0429936, 911938] Funding Source: Federal RePORTER
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Four trimethylated acylphloroglucinols (5-8) have been isolated from ircaanika (Leptospermum scoparium) foliage. Apart from myrigalone A (8), which has previously been isolated from European bog myrtle (Myrica gale), these compounds have not been characterized before. The nortriketones are structurally similar to the bioactive tetramethylated beta-triketones from rranuka, but have one less ring methyl group. Two oxidized trimethylated compounds, 9 and 10, were also isolated, but these are likely isolation artifacts. 'When evaluated for antibacterial activity against Gram-positive bacteria, myrigalone A (8) was slightly less potent (MIC 64 mu g/mL) than the corresponding tetramethylated compound, grandiflorone (4) (MIC 16-32 mu g/mL). Unlike their tetramethylated analogues, the nortriketones were inactive against the herbicide target enzyme p-hydroxyphenylpyruvate dioxygenase. The Raman spectra of leaf oil glands in different manuka varieties can be used to distinguish plants that contain nortriketones from those that accumulate triketones.
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