Journal
JOURNAL OF NATURAL MEDICINES
Volume 71, Issue 1, Pages 286-291Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-016-1030-0
Keywords
Cannabidiolic acid; Cyclooxygenase-2; c-fos; MDA-MB-231 cells; Fiber-type cannabis plant
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Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [25460182, 15K19167]
- Grants-in-Aid for Scientific Research [15K19167, 25460182, 16K08354] Funding Source: KAKEN
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The physiological activities of cannabidiolic acid (CBDA), a component of fiber-type cannabis plants, have been demonstrated and include its function as a protector against external invasion by inducing cannabinoid-mediated necrosis (Shoyama et al., Plant Signal Behav 3:1111-1112, 2008). The biological activities of CBDA have been attracting increasing attention. We previously identified CBDA as an inhibitor of the migration of MDA-MB-231 cells, a widely used human breast cancer cell line in cancer biology, due to its highly aggressive nature. The chemical inhibition and down-regulation of cyclooxygenase-2 (COX-2), the expression of which has been detected in similar to 40 % of human invasive breast cancers, are suggested to be involved in the CBDA-mediated abrogation of cell migration. However, the molecular mechanism(s) responsible for the CBDA-induced down-regulation of COX-2 in MDA-MB-231 cells have not yet been elucidated. In the present study, we describe a possible mechanism by which CBDA abrogates the expression of COX-2 via the selective down-regulation of c-fos, one component of the activator protein-1 (AP-1) dimer complex, a transcription factor for the positive regulation of the COX-2 gene.
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