Journal
GENE REPORTS
Volume 28, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.genrep.2022.101641
Keywords
COVID-19; SARS-CoV-2; miRNA
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This article summarizes the data on miRNA dysregulation in COVID-19. miRNAs are considered as factors affecting the course of COVID-19 and have potential therapeutic targets.
Coronavirus disease 2019 (COVID-19) is regarded as a challenge in health system. Several studies have assessed the immune-related aspect of this disorder to identify the host-related factors that affect the course of COVID-19. microRNAs (miRNAs) as potent regulators of immune responses have gained much attention in this regard. Recent studies have shown aberrant expression of miRNAs in COVID-19 in association with disease course. Differentially expressed miRNAs have been enriched in pathways related with inflammation and antiviral immune response. miRNAs have also been regarded as potential therapeutic targets in COVID-19, particularly for management of pathological consequences of COVID-19. In the current review, we summarize the data about dysregulation of miRNAs in COVID-19.
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