3.8 Article

Spend less to achieve more: Economic analysis of intermittent versus continuous cetuximab in KRAS wild-type patients with metastatic colorectal cancer

Related references

Note: Only part of the references are listed.
Article Oncology

Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212)

Dominik Paul Modest et al.

Summary: The PANAMA trial investigated the efficacy of adding panitumumab to maintenance therapy in patients with RAS wild-type metastatic colorectal cancer, and found that combining panitumumab with fluorouracil and folinic acid could significantly improve progression-free survival in these patients.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Treatments after second progression in metastatic colorectal cancer: A pooled analysis of the TRIBE and TRIBE2 studies

Daniele Rossini et al.

Summary: This study analyzed the treatment choices and outcomes for metastatic colorectal cancer patients after the second disease progression. The results showed a significant attrition rate across subsequent lines of therapy, especially in RAS and BRAF mutated patients. Among RAS/BRAF wild-type patients, anti-EGFR agents were found to be more effective than other options. The reintroduction of chemotherapy is common in clinical practice.

EUROPEAN JOURNAL OF CANCER (2022)

Review Oncology

Treatment breaks in first line treatment of advanced colorectal cancer: An individual patient data meta-analysis

Richard Adams et al.

Summary: The individual patient data meta-analysis showed that intermittent chemotherapy strategies for advanced colorectal cancer did not lead to inferior overall survival compared to continuous chemotherapy, regardless of whether it was a maintenance or complete break strategy. Thrombocytosis was confirmed as a marker of poor prognosis in aCRC, but was not predictive of poor outcome in patients treated with intermittent therapy.

CANCER TREATMENT REVIEWS (2021)

Article Gastroenterology & Hepatology

The economic burden of colorectal cancer across Europe: a population-based cost-of-illness study

Raymond Hugo Henderson et al.

Summary: The economic burden of colorectal cancer in Europe in 2015 was 19.1 billion euros, with non-healthcare costs accounting for 60.6% of the total burden and healthcare costs accounting for 39.4%. The average cost of managing a patient with colorectal cancer varied widely between countries.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Oncology

Current Status of Maintenance Systemic Therapies in Metastatic Colorectal Cancer: 2018 Update

Julia Mann et al.

CURRENT COLORECTAL CANCER REPORTS (2019)

Review Health Care Sciences & Services

Description of the health problem

Nicola Huxley et al.

HEALTH TECHNOLOGY ASSESSMENT (2017)

Review Oncology

Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine

Kamil A. Lipinski et al.

TRENDS IN CANCER (2016)

Correction Biochemistry & Molecular Biology

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients (vol 21, pg 795, 2015)

Giulia Siravegna et al.

NATURE MEDICINE (2015)

Article Medicine, General & Internal

K-ras mutations and benefit from cetuximab in advanced colorectal cancer

Christos S. Karapetis et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Oncology

Reintroduction of oxaliplatin is associated with improved survival in advanced colorectal cancer

Aimery de Gramont et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Article Economics

The death of cost-minimization analysis?

AH Briggs et al.

HEALTH ECONOMICS (2001)