Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 16, Issue 1, Pages 189-195Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2016.10683
Keywords
Polythiophene; Amphiphiles; Nanoparticles; Active Targeting; Cell Imaging
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Funding
- DGIST R&D Program of MSIP of Korea [14-NB-2]
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Polythiophene containing pendant N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeting fluorescent cellular imaging probe. The amphiphilic character of the folic acid-functionalized polythiophene induced the formation of nanoparticles with an average diameter of 95.3 rim in water. This polymer shows good photostability and low toxicity toward KB cells at a high concentration (100 mu g/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to yield bright fluorescence, indicating that it is a good candidate material for the fluorescence imaging of living cells.
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