Journal
INTERNATIONAL CANCER CONFERENCE JOURNAL
Volume 12, Issue 1, Pages 63-68Publisher
SPRINGER INT PUBL AG
DOI: 10.1007/s13691-022-00579-2
Keywords
Endometrial cancer; Lower uterine segment; Dedifferentiated carcinoma; Squamous cell carcinoma; Lynch syndrome
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In this report, we present a case of a patient who was initially diagnosed with locally advanced cervical squamous cell carcinoma but was later found to have endometrial cancer with prominent squamous differentiation after surgical treatment.
Locally advanced cervical squamous cell carcinoma is a rare indication for surgery. In this report, we describe the case of a patient with presumed locally advanced cervical squamous cell carcinoma who underwent surgical treatment and was postoperatively diagnosed with endometrial cancer with prominent squamous differentiation. A 41-year-old woman presented with squamous cell carcinoma that was detected via Pap smear and confirmed by histological diagnosis of cervical biopsy. Magnetic resonance imaging showed a bulky cervical mass that spread to the lower uterine segment, vaginal wall, and rectum. The initial diagnosis was cervical cancer stage IVA. The patient underwent neoadjuvant chemotherapy followed by radical hysterectomy with combined rectal resection. Postoperative histopathology revealed a dedifferentiated carcinoma of the uterine corpus with prominent squamous differentiation. Immunohistochemistry of the surgical specimen showed loss of expression of mismatch repair proteins. The patient was informed of the possibility of Lynch syndrome and was recommended genetic counseling.
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