4.4 Article

Species variation in the cartilaginous endplate of the lumbar intervertebral disc

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Single Impact Injury of Vertebral Endplates Without Structural Disruption, Initiates Disc Degeneration Through Piezo1 Mediated Inflammation and Metabolism Dysfunction

Zhengang Sun et al.

Summary: This in vitro experimental study aimed to establish an axial impact injury model of intervertebral disc (IVD) and investigate whether a single impact injury without endplate structural disruption could initiate intervertebral disc degeneration (IDD), as well as the roles of Piezo1 in this process. The study found that both fracture of the endplate and a single impact injury without structural impairment could initiate IDD, possibly mediated by activation of Piezo1-induced inflammation and abnormal energy metabolism of IVD cells.

SPINE (2022)

Article Orthopedics

In vivo fluid transport in human intervertebral discs varies by spinal level and disc region

John T. Martin et al.

Summary: This study used MRI to quantify diurnal changes in lumbar disc fluid and found variations in fluid transport along the spinal level.

JOR SPINE (2022)

Review Rheumatology

Cell-based strategies for IVD repair: clinical progress and translational obstacles

Abbie L. A. Binch et al.

Summary: Intervertebral disc degeneration is a common cause of low back pain, with current lack of approved pharmacological interventions to prevent its progression. Cell-based therapies are emerging as promising approaches for repairing the degenerated discs, but face various challenges in terms of understanding disease mechanisms, standardizing preclinical testing, and defining guidelines for clinical trials.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Orthopedics

Transcriptional profiling of intervertebral disc in a post-traumatic early degeneration organ culture model

Shangbin Cui et al.

Summary: This study characterized transcriptome changes and gene regulation networks in an organ culture system mimicking early post-traumatic intervertebral disc degeneration. The results revealed different DEGs, pathways, biological processes, and PPI networks involved in post-traumatic IVD degeneration, advancing understanding of the disease pathogenesis and identifying potential novel biomarkers for diagnosis.

JOR SPINE (2021)

Article Orthopedics

Inhibition of both endplate nutritional pathways results in intervertebral disc degeneration in a goat model

Si Yin et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2019)

Review Rheumatology

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair

Feng-Juan Lyu et al.

NATURE REVIEWS RHEUMATOLOGY (2019)

Review Biochemistry & Molecular Biology

Recent Approaches to the Manufacturing of Biomimetic Multi-Phasic Scaffolds for Osteochondral Regeneration

Ryan Longley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Rheumatology

Molecular transport in articular cartilage - what have we learned from the past 50 years?

Chris D. DiDomenico et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

Review Cell & Tissue Engineering

Biomaterials for intervertebral disc regeneration: Current status and looming challenges

Yong-Can Huang et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

Article Orthopedics

Compositional mapping of the mature anterior cruciate ligament-to-bone insertion

Dovina Qu et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

Article Orthopedics

Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI

Hui Li et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2017)

Article Orthopedics

The micromechanics of the superficial zone of articular cartilage

J. C. Mansfield et al.

OSTEOARTHRITIS AND CARTILAGE (2015)

Article Clinical Neurology

Surgical technique for lumbar intervertebral disc transplantation in a goat model

Jun Xiao et al.

EUROPEAN SPINE JOURNAL (2015)

Article Endocrinology & Metabolism

FTIR-I Compositional Mapping of the Cartilage-to-Bone Interface as a Function of Tissue Region and Age

Nora T. Khanarian et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Rheumatology

OPINION Intervertebral disc regeneration: do nutrients lead the way?

Yong-Can Huang et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

Article Anatomy & Morphology

On how nucleus-endplate integration is achieved at the fibrillar level in the ovine lumbar disc

Kelly R. Wade et al.

JOURNAL OF ANATOMY (2012)

Article Multidisciplinary Sciences

Mineral Distributions at the Developing Tendon Enthesis

Andrea G. Schwartz et al.

PLOS ONE (2012)

Article Clinical Neurology

Micromechanics of annulus-end plate integration in the intervertebral disc

Samantha A. Rodrigues et al.

SPINE JOURNAL (2012)

Article Clinical Neurology

A fresh look at the nucleus-endplate region: new evidence for significant structural integration

Kelly R. Wade et al.

EUROPEAN SPINE JOURNAL (2011)

Article Biochemistry & Molecular Biology

Histomorphometric analysis of adult articular calcified cartilage zone

Fuyou Wang et al.

JOURNAL OF STRUCTURAL BIOLOGY (2009)

Review Clinical Neurology

Are animal models useful for studying human disc disorders/degeneration?

Mauro Alini et al.

EUROPEAN SPINE JOURNAL (2008)

Article Pathology

The collagen superfamily: from the extracellular matrix to the cell membrane

S Ricard-Blum et al.

PATHOLOGIE BIOLOGIE (2005)

Article Engineering, Biomedical

Intervertebral disc cell therapy for regeneration: Mesenchymal stem cell implantation in rat intervertebral discs

G Crevensten et al.

ANNALS OF BIOMEDICAL ENGINEERING (2004)

Article Clinical Neurology

The effect of blocking a nutritional pathway to the intervertebral disc in the dog model

WC Hutton et al.

JOURNAL OF SPINAL DISORDERS & TECHNIQUES (2004)

Article Clinical Neurology

Experimental disc degeneration due to endplate injury

S Holm et al.

JOURNAL OF SPINAL DISORDERS & TECHNIQUES (2004)

Article Clinical Neurology

Nutrition of the intervertebral disc

JPG Urban et al.

SPINE (2004)

Article Orthopedics

Histologic changes after vertebroplasty

JJ Verlaan et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2004)

Review Clinical Neurology

Biomechanics of the aging spine

SJ Ferguson et al.

EUROPEAN SPINE JOURNAL (2003)