Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1113, Issue -, Pages 162-170Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2016.02.045
Keywords
Ferrocene; Modal membrane; Antitumor cell line; Human ovarian tumor
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Funding
- Higher Education Commission (HEC) Pakistan [PD-IPFP/HRD/HEC/2013/30240]
- NSF USA [CHE-0628260]
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A series of nitrophenyl ferrocens (A1-A5) were synthesized and fully characterized in solid state (using CHN analysis, FTIR and single crystal XRD) as well as in solution phase (H-1 & C-13 NMR and UV-visible spectroscopy). Micelle interface interactions of these compounds were explored and found to have ability across a micelle membrane interface. Interestingly, these compounds exhibited pi-electronic push pull systems and oxidation of ferrocene to ferrocenium on crossing the negative interface of the micelle membrane. Selective compounds were screened for antitumor activity against parental and drug resistant, human ovarian tumor models i.e. A2780 and A2780(clsR) A2780(ZD0473R). Screened compounds were found to overcome resistance factor compared to cisplatin. (C) 2016 Elsevier B.V. All rights reserved.
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