Journal
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY
Volume 26, Issue 6, Pages 389-400Publisher
KARGER
DOI: 10.1159/000448842
Keywords
Morbillivirus; Peste des petits ruminants virus; Systems virology; Viroinformatics; Host-pathogen interaction
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Funding
- Department of Science and Technology, Government of India [SB/SO/AS-20/2014]
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Systems biology refers to system-wide changes in biological components such as RNA/DNA (genomics), protein (proteomics) and lipids (lipidomics). In this review, we provide comprehensive information about morbillivirus replication. Besides discussing the role of individual viral/host proteins in virus replication, we also discuss how systems-level analyses could improve our understanding of morbillivirus replication, host-pathogen interaction, immune response and disease resistance. Finally, we discuss how viroinformatics is likely to provide important insights for understanding genome-genome, genome-protein and protein-protein interactions. (C) 2016 S. Karger AG, Basel.
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