Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 94, Issue 10, Pages 1085-1093Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-016-1423-2
Keywords
Innate immunity; DNA sensing; Type I interferons
Funding
- Swiss National Science Foundation [BSSGI0-155984, 31003A_159836]
- Gebert Ruf Stiftung [GRS-059_14]
- Swiss National Science Foundation (SNF) [BSSGI0_155984, 31003A_159836] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyond infection, accumulating evidence indicates that cGAS is also active during autoimmune diseases and controls immune responses that underlie cancer immunosurveillance. In this review, we highlight our current understanding of DNA sensing by cGAS and its involvement in human disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available