HIV Patients Have Impaired Diastolic Function that is Not Aggravated by Anti-Retroviral Treatment

Recent studies have shown that HIV infection is independently associated with heart failure. Diastolic dysfunction (DD) is frequent in HIV patients, but it is unclear whether this is an effect of the HIV infection itself or of the anti-retroviral therapy (ART). Our aim was to compare diastolic function in HIV treatment-na < ve, HIV-ART patients and controls. We prospectively enrolled 206 consecutive patients with HIV-1 infection and 30 controls, selected by frequency matching for age and sex. HIV patients were divided in two subgroups: ART-na < ve (n = 88) and ART (n = 118). Diastolic function was assessed and graded by echocardiography, according to modern consensus criteria and using tissue Doppler analysis. Compared to controls, ART-na < ve patients had lower E' velocities (E' septal: 10.2 +/- 2.4 vs 11.9 +/- 2.6 cm/s, p = 0.02), higher E/E' ratio (7.8 +/- 1.9 vs 6.9 +/- 1.6,p = 0.02) and higher prevalence of DD (19 % vs 3.3 %,p = 0.05). HIV patients under ART also had worse diastolic function compared to controls (E' septal: 10.3 +/- 2.5 cm/s;p < 0.01; E/E'ratio: 8.0 +/- 2.0,p < 0.01; DD prevalence: 23 %;p = 0.01), but no significant differences were found between ART-na < ve and ART HIV subgroups. In multivariable logistic regression analysis, age and body mass index were the only independent predictors of reduced diastolic reserve in HIV patients. Regarding systolic function, there were no significant differences in ejection fraction or S' velocities between controls and HIV subgroups. HIV treatment-na < ve patients have reduced diastolic reserve that is not worsened by ART. These data reinforce the association of diastolic dysfunction with the HIV infection itself and not with the anti-retroviral therapy.