Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 216, Issue -, Pages 360-363Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2016.01.047
Keywords
Dronedarone hydrochloride; Solubility; Correlation
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2014R1A1A1006492]
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The aim of this study was to measure the mole fraction solubility of dronedarone hydrochloride in six pure solvents across a temperature range of 298.15-323.15 K. The experimental solubility of dronedarone hydrochloride correlated with the Apelblat equation. The maximum mole fraction solubility of dronedarone hydrochloride was observed to be 0.119 in methanol at 323.15 K followed by ethanol (3.62 x 10(-2) at 323.15 K), 1-propanol (1.59 x 10(-2) at 323.15 K), 1-butanol (8.05 x 10(-3) at 323.15 K), 2-propanol (2.93 x 10(-3) at 323.15 K), and water (6.11 x 10(-5) at 323.15 K). Based on these results, dronedarone hydrochloride can be considered freely soluble in methanol, soluble in ethanol, and slightly soluble in 1-propanol, 2-propanol, 1-butanol, and water. These data could be important for the recrystallization and formulation development of dronedarone hydrochloride. (C) 2016 Elsevier B.V. All rights reserved.
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