Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 216, Issue -, Pages 429-439Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2015.12.094
Keywords
Promethazine hydrochloride; Self-assembled monolayer; Electrocatalytic oxidation; Gold electrode
Funding
- University of Qom
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In this study, a new Schiff base of bis-N-(2-mercaptophenyl) salicylaldimine (MPSI) has been immobilized on a bare gold electrode as a novel self assembled monolayer (SAM) sensor for determination of promethazine hydrochloride (PMZ). Cyclic voltammetry and electrochemical impedance spectroscopy are used to study the properties of monolayer of SchifPs base on a gold electrode (MPSI-Au SAM electrode) using the [Fe(CN)(6)](3-/4-) probe. Also, the characterization of the MPSI-Au electrode was performed by scanning electron (SEM) and atomic force microscopy (AFM). The electrochemical behavior of PMZ on the MPSI-Au SAM electrode was studied by several voltammetry methods in phosphate buffer solution as supporting electrolyte. The modified electrode showed good selectivity in the presence of interference of ascorbic and uric acid. A calibration curve was obtained for PMZ in a linear range of 1.0-240.0 mu mol L-1. The detection limit for promethazine hydrochloride was found to be 24.6 nmol L-1. The results indicated that the MPSI-Au SAM electrode could be employed for the determination of promethazine hydrochloride in urine and plasma samples. (C) 2015 Elsevier B.V. All rights reserved.
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