Journal
INDIAN JOURNAL OF CRITICAL CARE MEDICINE
Volume 26, Issue 11, Pages 1182-1189Publisher
JAYPEE BROTHERS MEDICAL PUBLISHERS PVT LTD
DOI: 10.5005/jp-journals-10071-24349
Keywords
BBV152; Breakthrough infection; ChAdOx1 nCOV19; Covaxin; COVID-19; COVID vaccination; Delta variant; ICU; Multicenter study
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This study analyzed the risk factors associated with mortality in critically ill COVID-19-vaccinated patients admitted to the ICU. It was found that receiving a single dose, neutrophil:lymphocyte ratio, and SOFA score were associated with higher mortality. The mortality rate in vaccinated ICU patients was 43.68%, with lower mortality in patients who had received two doses.
Background: Emergency authorization and approval were given for the coronavirus disease-19 (COVID-19) vaccines. The efficacy reported after phase III trials were 70.4% and 78% for Covishield and Covaxin, respectively. In this study, we aim to analyze the risk factors, which were associated with mortality in critically ill COVID-19-vaccinated patients admitted into intensive care unit (ICU).Methods:This study was conducted from April 1, 2021 to December 31, 2021 across five centers in India. Patients who had received either one or two doses of any of the COVID vaccines and developed COVID-19 were included. The ICU mortality was a primary outcome.Results: A total of 174 patients with COVID-19 illness were included in the study. The mean age was 57 years standard deviation (SD 15). Acute physiology, age and chronic health evaluation (APACHE II) score and the sequential organ failure assessment (SOFA) score were 14 (8-24.5) and 6 (4-8), respectively. Multiple variable logistic regression showed patients who have received a single dose [odds ratio (OR): 2.89, confidence interval (CI): 1.18, 7.08], neutrophil:lymphocyte (NL) ratio (OR: 1.07, CI: 1.02,1.11), and SOFA score (OR: 1.18, CI: 1.03,1.36) were associated with higher mortality.Conclusion:The mortality in the vaccinated patients admitted to the ICU was 43.68% due to COVID illness. The mortality was lower in patients who had received two doses.
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