Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 9, Pages 1714-1724Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2016.02.004
Keywords
autophagy; autophagosome; cargo receptor; isolation membrane; Atg8
Categories
Funding
- ERC [260304]
- FWF [P25546-B20]
- EMBO Young Investigator Program
- Uni:docs Program of the University of Vienna
- European Research Council (ERC) [260304] Funding Source: European Research Council (ERC)
- Austrian Science Fund (FWF) [P25546] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 25546] Funding Source: researchfish
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Selective autophagy contributes to intracellular homeostasis by mediating the degradation of cytoplasmic material such as aggregated proteins, damaged or over-abundant organelles, and invading pathogens. The molecular machinery for selective autophagy must ensure efficient recognition and sequestration of the cargo within autophagosomes. Cargo specificity can be mediated by autophagic cargo receptors that specifically bind the cargo material and the autophagosomal membrane. Here we review the recent insights into the mechanisms that enable cargo receptors to confer selectivity and exclusivity to the autophagic process. We also discuss their different roles during starvation-induced and selective autophagy. We propose to classify autophagic events into cargo-independent and cargo-induced autophagosome formation events. (C) 2016 The Authors. Published by Elsevier Ltd.
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