Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 10, Pages 1962-1985Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2015.09.016
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Funding
- German Research Foundation
- European Research Council [AN377/3-2, 309528 CHROMDECON]
- Boehringer Ingelheim Fonds
- International Max Planck Research School From Molecules to Organisms
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Cells have developed highly sophisticated ways to accurately pass on their genetic information to the daughter cells. In animal cells, which undergo open mitosis, the nuclear envelope breaks down at the beginning of mitosis and the chromatin massively condenses to be captured and segregated by the mitotic spindle. These events have to be reverted in order to allow the reformation of a nucleus competent for DNA transcription and replication, as well as all other nuclear processes occurring in interphase. Here, we summarize our current knowledge of how, in animal cells, the highly compacted mitotic chromosomes are decondensed at the end of mitosis and how a nuclear envelope, including functional nuclear pore complexes, reassembles around these decondensing chromosomes. Crown Copyright (c) 2015 Published by Elsevier Ltd.
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