Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 12, Pages 2636-2651Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2016.03.004
Keywords
DNA damage response; p53; RNA processing; alternative splicing; ncRNAs
Categories
Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas of Argentina (CONICET)
- Universidad de Buenos Aires
- European Union [661051]
- Agencia Nacional de Promocion de Ciencia y Tecnologia of Argentina
- Marie Curie Actions (MSCA) [661051] Funding Source: Marie Curie Actions (MSCA)
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Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins. Accumulated evidence over the past decades has shown that RNAs and RNA metabolism are both regulators and regulated actors of the DDR. This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields. (C) 2016 Elsevier Ltd. All rights reserved.
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