Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 3, Pages 554-560Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2016.01.013
Keywords
Fratricide; sporulation; patterning; bacteriocin; DfsB
Categories
Funding
- Wellcome Trust [100280, 104833]
- Medical Research Council [G1001664] Funding Source: researchfish
- Wellcome Trust [100280/Z/12/Z] Funding Source: researchfish
- Wellcome Trust [100280/Z/12/Z] Funding Source: Wellcome Trust
- MRC [G1001664, MR/J006874/1] Funding Source: UKRI
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Bacteria have developed a variety of mechanisms for surviving harsh environmental conditions, nutrient stress and overpopulation. Paenibacillus dendritiformis produces a lethal protein (Slf) that is able to induce cell death in neighbouring colonies and a phenotypic switch in more distant ones. Slf is derived from the secreted precursor protein, DfsB, after proteolytic processing. Here, we present new crystal structures of DfsB homologues from a variety of bacterial species and a surprising version present in the yeast Saccharomyces cerevisiae. Adopting a four-helix bundle decorated with a further three short helices within intervening loops, DfsB belongs to a non-enzymatic class of the DinB fold. The structure suggests that the biologically active Slf fragment may possess a C-terminal helix rich in basic and aromatic residues that suggest a functional mechanism akin to that for cationic antimicrobial peptides. (C) 2016 The Authors. Published by Elsevier Ltd.
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