Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 428, Issue 5, Pages 1004-1021Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2015.09.003
Keywords
genomically recoded organism (GRO); expanded genetic code; genome engineering
Categories
Funding
- U.S. Department of Energy [DE-FG02-02ER63445, DE-FG02-98ER20311]
- National Science Foundation [SA5283-11210]
- National Institutes of Health [GM22854]
- Defense Advanced Research Projects Agency [N66001-12-C-4040, N66001-12-C-4020, N66001-12-C-4211]
- U.S. Department of Energy (DOE) [DE-FG02-98ER20311] Funding Source: U.S. Department of Energy (DOE)
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Withstanding 3.5 billion years of genetic drift, the canonical genetic code remains such a fundamental foundation for the complexity of life that it is highly conserved across all three phylogenetic domains. Genome engineering technologies are now making it possible to rationally change the genetic code, offering resistance to viruses, genetic isolation from horizontal gene transfer, and prevention of environmental escape by genetically modified organisms. We discuss the biochemical, genetic, and technological challenges that must be overcome in order to engineer the genetic code. (C) 2015 Elsevier Ltd. All rights reserved.
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