Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 92, Issue -, Pages 41-45Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2016.01.018
Keywords
T-cells; Myocardial fibrosis; Healing; Myocardial infarction
Categories
Funding
- Bundesministerium fur Bildung und Forschung [BMBF01 EO1004]
- German Research Foundation [DFG SFB688, TP A10]
- Brazilian National Council for Scientific and Technological Development
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Lymphocytes came recently into focus as modulators of non-infectious myocardial diseases. Several lines of experimental evidence now indicate that CD4(+) T-cells can influence the healing and scarring processes that follow a myocardial infarction episode. Furthermore, such heart-directed T-cell activity has also been implicated in the pathogenesis cardiac remodeling that develops in response to chronic pressure-overload conditions. Mechanistically, different T-cell subsets can secrete several mediators and growth factors that influence the myocardial molecular milieu and directly interfere with the macrophages' and fibroblasts' activity. Therefore, the present review summarizes the current experimental evidence on the role of T-cells in myocardial scar formation after infarction and myocardial fibrosis as central mechanism of ventricular remodeling. (C) 2016 Elsevier Ltd. All rights reserved.
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