Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 91, Issue -, Pages 238-246Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2016.01.010
Keywords
Scar; Gap junction; Cardiac electrophysiology
Categories
Funding
- NIH [F31DE22224]
- European Research Council CardioNECT Advanced Grant
- BBSRC
- British Heart Foundation [NH/13/1/30238, FS/12/17/29532] Funding Source: researchfish
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Cardiac myocyte-fibroblast electrotonic coupling is a well-established fact in vitro. Indirect evidence of its presence in vivo exists, but few functional studies have been published. This review describes the current knowledge of fibroblast-myocyte electrical signaling in the heart. Further research is needed to understand the frequency and extent of heterocellular interactions in vivo in order to gain a better understanding of their relevance in healthy and diseased myocardium. It is hoped that associated insight into myocyte-fibroblast coupling in the heart may lead to the discovery of novel therapeutic targets and the development of agents for improving outcomes of myocardial scarring and fibrosis. (C) 2016 Elsevier Ltd. All rights reserved.
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